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THE ROLES OF HEDGEHOG, PTEN, AND ETS2 SIGNALING IN THE REGULATION OF PANCREATIC TUMORIGENESIS BY STROMAL FIBROBLASTS

Pitarresi, Jason Robert
http://rave.ohiolink.edu/etdc/view?acc_num=osu1467733840

Abstract Details

2016, Doctor of Philosophy, Ohio State University, Biochemistry Program, Ohio State.
Pancreatic cancer is an overwhelming fatal disease with less than 5% of patients surviving beyond 5 years. The most prominent histopathological hallmark of pancreatic cancer is its uniquely dense stromal reaction, which has historically been considered pro-tumorigenic. However, the true role that the pancreatic stroma plays in tumorigenesis, from initiation to maintenance, has come under intense examination in the past few years. Recent reports have focused on stromal fibroblasts, the most abundant cell within the pancreatic tumor microenvironment, and have highlighted both their pro- and anti-tumorigenic effect in pancreatic cancer. These studies have shown that crosstalk between the evolving tumor cell and the adjacent fibroblasts involves complex paracrine signaling networks that are just now becoming more well understood. Despite these efforts, few groups have looked at signaling networks within the fibroblasts to determine molecular mechanisms that drive fibroblasts to have a pro- or anti-tumor function. To this end, our work has used novel genetically engineered mouse models to look at the effects of disrupting Hedgehog, PTEN, and ETS2 signaling networks in pancreatic fibroblasts. We provide new insight into each of these signaling networks and show that each pathway is, in its own unique way, an important mediator of essential functions for tumor associated fibroblasts in both promoting and suppressing pancreatic tumor formation.
Michael Ostrowski (Advisor)
Denis Guttridge (Committee Member)
Gregory Lesinski (Committee Member)
Vincenzo Coppola (Committee Member)
234 p.
Biochemistry
hedgehog, tumor microenvironment, stroma

Recommended Citations

Citations

  • Pitarresi, J. R. (2016). THE ROLES OF HEDGEHOG, PTEN, AND ETS2 SIGNALING IN THE REGULATION OF PANCREATIC TUMORIGENESIS BY STROMAL FIBROBLASTS [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1467733840

    APA Style (7th edition)

  • Pitarresi, Jason. THE ROLES OF HEDGEHOG, PTEN, AND ETS2 SIGNALING IN THE REGULATION OF PANCREATIC TUMORIGENESIS BY STROMAL FIBROBLASTS. 2016. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1467733840.

    MLA Style (8th edition)

  • Pitarresi, Jason. "THE ROLES OF HEDGEHOG, PTEN, AND ETS2 SIGNALING IN THE REGULATION OF PANCREATIC TUMORIGENESIS BY STROMAL FIBROBLASTS." Doctoral dissertation, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1467733840

    Chicago Manual of Style (17th edition)

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© 2016, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.