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Canan Dissertation.pdf (2.13 MB)

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Impacts of Aging and Inflammation on Mycobacterium tuberculosis Control

Canan, Cynthia Hsin-Tzu
http://rave.ohiolink.edu/etdc/view?acc_num=osu1479895740309589

Abstract Details

2016, Doctor of Philosophy, Ohio State University, Biomedical Sciences.
The global demographic is shifting at a dramatic rate. Between the years 2000 and 2050, the number of individuals 60 years and older is expected to double accounting for more than 20% of the total population worldwide. This shift in the distribution of the population is primarily a consequence of decreased fertility rates in women and increased life expectancy of elderly individuals. Although people are getting older, there is little evidence to suggest that they are also getting heathier. The World Health Organization recently reported that there has been no significant change in the rates of mild to moderate disability, including susceptibility to infectious disease, of elderly individuals in high-income countries. Increased susceptibility to infection in old age is made even more evident by the disproportionate rate of influenza, pneumonia and Mycobacterium tuberculosis infections with advanced age. Disease progression in the elderly is often prolonged and exacerbated leading to increased morbidity and mortality. In this work, we sought to gain further understanding of immune changes that can lead to disease susceptibility with advanced age. Aging is often accompanied by a low-grade, systemic inflammation term inflammaging, which has been implicated in several age-associated diseases including coronary heart disease and Alzheimer’s disease. Recently, inflammaging has been proposed to alter immune function in elderly individuals, although direct support for this concept is lacking. In this work, we demonstrate that old mice can also experience inflammaging, suggesting an evolutionarily conserved phenotype. We also demonstrate that inflammation in old age is associated with altered immune function. By modulating inflammation in both young and old mice, we were able to further define the impact of inflammation during Mycobacterium tuberculosis infection. Overall, this collective work expands upon our understanding of inflammation induced immune changes and how susceptibility to infectious disease in old age may be altered to enhance the lifespan and health span of elderly individuals.
Joanne Turner (Advisor)
Prosper Boyaka (Committee Member)
Larry Schlesinger (Committee Member)
Susheela Tridandapani (Committee Member)
205 p.
Biomedical Research; Immunology
Mycobacterium tuberculosis; inflammaging; aging

Recommended Citations

Citations

  • Canan, C. H.-T. (2016). Impacts of Aging and Inflammation on Mycobacterium tuberculosis Control [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479895740309589

    APA Style (7th edition)

  • Canan, Cynthia. Impacts of Aging and Inflammation on Mycobacterium tuberculosis Control. 2016. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1479895740309589.

    MLA Style (8th edition)

  • Canan, Cynthia. "Impacts of Aging and Inflammation on Mycobacterium tuberculosis Control." Doctoral dissertation, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479895740309589

    Chicago Manual of Style (17th edition)

osu1479895740309589
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© 2016, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.