Preventable chronic diseases, as well as mortality from these diseases, are experienced at a much higher rate among African American women than their racial counterparts. Eight-two percent of African American women are overweight or obese and are less likely to be physically active than other Americans. Similar to many Americans, African American women are failing to consume the recommended amount of fruits and vegetables. The purpose of this study was to assess the effectiveness of Project LIFE (Lifestyle Improvement through Faith and Empowerment), a culturally tailored, faith based intervention designed to increase physical activity (PA) and improve nutrition among African American women. It was hypothesized that Project LIFE would lead to increases in PA and healthy dietary change among African American women, as well as weight loss among overweight or obese African American women compared to a waitlist control group. This study was designed based on the theoretical framework of the Transtheoretical Model (TTM). The participants were thirty-nine African American women recruited for a quasi-experimental Pretest-Posttest Waitlist Control Group Design (Thomas & Nelson, 2001) consisting of two groups measured at baseline, 10 weeks, and 14 weeks. The main outcome variables of interest were: (a) minutes of PA, (b) dietary habits, (c) weight, (d) body mass index (BMI), (e) body fat percentage, (f) waist-to-hip ratio, (g) aerobic fitness, and (h) muscular strength. Primary sources of data were questionnaires and anthropometric measures. General linear model ANOVA was used to assess between-group and within-group differences across three different time points (1 = baseline, 2 = 10 weeks, 3 = 14 weeks). Means and standard deviations were used to compare differences and effect sizes were calculated, whenever statistical significance was found, to determine magnitude of the impact of the intervention. The alpha level was set a priori at p < 0.05 for all inferential statistical analyses. The results show that all three measures of physical activity (moderate, hard to very hard, and total) had a significant interaction effect [moderate F(2,37) = 4.62, p =.013; hard-very hard F(2, 37) = 13.95, p = .000; total F(2, 37) = 9.61, p = .000]. The intervention group continued to increase for all three measures of physical activity across all time points. Total minutes of PA for the intervention group were M = 83.5, 311.3, and 397 for DCP 1, 2, and 3, respectively. For nutrition, eight of the 13 variables assessed showed a significant interaction effect, with two of those variables changing in favor of the WLCG. There was also significant change for aerobic fitness. There was an interaction effect, F(2, 37) = 4.38, p = .016 with DCP 2 showing the largest mean difference between the intervention group (M = 405.0, SD = 75.7) and the control group (M = 359.7, SD = 87.2). Among the variables assessed that showed significant change, only those variables tied to physical activity time and the dairy component of the HEI showed sustained change from DCP 2 to DCP 3. There were no significant changes for any of the variables associated with body composition (i.e., weight, waist-to-hip ratio, body fat percentage, and BMI) or upper and lower body strength.