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Tear Film Dynamics Associated with Contact Lens Wear

McClure, Kate Alexandra
http://orcid.org/0000-0003-4911-3244
http://rave.ohiolink.edu/etdc/view?acc_num=osu1523579680091666

Abstract Details

2018, Master of Science, Ohio State University, Vision Science.
Contact lens wear is known to disrupt the tear film and cause tear film instability, yet there is insufficient research to quantify these changes. This study aimed to investigate how contact lens wear and materials influence tear film stability by obtaining quantifiable metrics of the prelens tear film and its effect on visual performance and subjective contact lens comfort. Lipid layer thickness, measured by interferometry, was used to quantify tear film stability. Visual performance was assessed with high and low contrast Bailey-Lovie charts. The Contact Lens Dry Eye Quesionnaire-8 (CLDEQ-8) was issued to assess subjective contact lens comfort. 10 subjects participated in the study. At the initial visit the baseline precorneal tear film lipid layer thickness was measured. The subject was then fit with one of the 2 contact lenses chosen for the study, Dailies Total1 or 1-Day Acuvue Moist. Lipid layer thickness and high and low contrast visual acuity was measured 5 and 15 minutes after contact lens insertion. The CLDEQ-8 was issued to assess initial contact lens comfort. The subject wore the contact lens for 6 hours, then returned for repeat measurements of lipid layer thickness, high and low contrast visual acuity, and the CLDEQ-8 assessment. After a washout period, the subject was fit with the other contact lens and the same procedures were performed. Paired t-tests were used to make all statistical comparisons. There was a trend towards decreased lipid layer thickness in Dailies Total1, but it was not found to be statistically significant. When the baseline precorneal lipid layer thickness was compared to the prelens lipid layer thickness after 6 hours of contact lens wear in Dailies Total1, there was a statically significant decline (-6.75 ± 7.90 nm, p = 0.02). In 1-Day Acuvue Moist the lipid layer thickness was more variable and the only decline in lipid layer thickness was from 15 minutes to 6 hours (-5.22 ± 7.30 nm, p = 0.05). There was no change in high contrast acuity but a subtle decline in low contrast acuity in Dailies Total1 (0.02 ± 0.08, p = 0.54) and 1-Day Acuvue Moist (0.07 ± 0.11, p = 0.06) was found after 6 hours. There was no significant change in CLDEQ-8 scores for Dailies Total1 after 6 hours of wear (+0.40 ± 4.55, p = 0.79). In 1-Day Acuvue Moist there was a clinically and statistically significant decline in contact lens comfort after 6 hours of wear (+3.7 ± 4.35, p = 0.03). Contact lens wear impacts tear film stability and can be quantified, however, it is variable among different contact lens materials. The visual disturbance associated with contact lens tear film instability may be detected by low contrast logMAR visual acuity. The symptoms related to contact lens induced tear film instability can be quantified using the CLDEQ-8. The changes that occur in the tear film induced by a contact lens are complex and several different mechanisms likely contribute to tear film instability and contact lens dry eye.
Dean VanNasdale, OD, PhD (Advisor)
Nicky Lai, OD, MS (Committee Member)
Joseph Barr, OD, MS (Committee Member)
Alex Nixon, OD, MS (Committee Member)
52 p.
Ophthalmology; Optics
contact lens; dry eye; interferometry; visual performance; soft contact lens; contact lens dry eye; tear film dynamics

Recommended Citations

Citations

  • McClure, K. A. (2018). Tear Film Dynamics Associated with Contact Lens Wear [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523579680091666

    APA Style (7th edition)

  • McClure, Kate. Tear Film Dynamics Associated with Contact Lens Wear. 2018. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1523579680091666.

    MLA Style (8th edition)

  • McClure, Kate. "Tear Film Dynamics Associated with Contact Lens Wear." Master's thesis, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523579680091666

    Chicago Manual of Style (17th edition)

osu1523579680091666
556
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This open access ETD is published by The Ohio State University and OhioLINK.