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MG53 protein protects aortic valve interstitial cells from membrane injury and fibrocalcific remodeling

Adesanya, T.M. Ayodele
http://rave.ohiolink.edu/etdc/view?acc_num=osu1534515427092756

Abstract Details

2018, Doctor of Philosophy, Ohio State University, Biomedical Sciences.
The aortic valve of the heart experiences constant mechanical stress under physiological conditions. Maladaptive valve injury responses contribute to the development of valvular heart disease (VHD). Here, we test the hypothesis that MG53, an essential cell membrane repair protein, can protect valvular cells from physical injury and fibrocalcific remodeling processes associated with VHD. We found that MG53 is expressed in pig and human patient aortic valves and observed aortic valve disease in aged Mg53-/- mice. Furthermore, aortic valves of Mg53-/- mice showed compromised cell membrane integrity. In vitro studies demonstrated that MG53 protects primary valve interstitial cells (VICs) from mechanical injury and that, in addition to mediating membrane repair, recombinant human MG53 (rhMG53) can enter VICs and suppress TGF--dependent activation of fibrocalcific signaling. Together, our data characterize VIC membrane repair as a novel mechanism of protection against valvular remodeling and assess potential in vivo roles of MG53 in preventing VHD.
Jianjie Ma, Ph.D. (Advisor)
Joanna Groden, Ph.D. (Committee Chair)
Joy Lincoln, Ph.D. (Committee Member)
Peter Mohler, Ph.D. (Committee Member)
Hua Zhu, Ph.D. (Committee Member)
163 p.
Biomedical Research

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Citations

  • Adesanya, T.M. A. (2018). MG53 protein protects aortic valve interstitial cells from membrane injury and fibrocalcific remodeling [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534515427092756

    APA Style (7th edition)

  • Adesanya, T.M. Ayodele. MG53 protein protects aortic valve interstitial cells from membrane injury and fibrocalcific remodeling . 2018. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1534515427092756.

    MLA Style (8th edition)

  • Adesanya, T.M. Ayodele. "MG53 protein protects aortic valve interstitial cells from membrane injury and fibrocalcific remodeling ." Doctoral dissertation, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534515427092756

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.