Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


David Gutschick Full Dissertation.pdf (6.09 MB)

ETD Abstract Container

Abstract Header

Characterization of Soft Gels with 2P Microrheology, a Novel, Active Paired-Particle Method

Gutschick, David D
http://rave.ohiolink.edu/etdc/view?acc_num=osu1534742722866439

Abstract Details

2018, Doctor of Philosophy, Ohio State University, Materials Science and Engineering.
The mechanics of a material will deviate from macroscopic values as the probe length scale approaches that of structural features in the material. This divergence of properties at small length scales can have major implications, such as for inter-cell communication in bio-matrices. Microrheology is well-situated to measure micromechanics in soft materials, but the state of the art has not been developed sufficiently to fully characterize micromechanics. This dissertation presents 2P active microrheology, a novel method to measure the micromechanics of soft gels versus particle separation distance. Findings from use of the 2P method are shown for polyacrylamide gels, agarose gels, and collagen gels with and without addition of non-collagenous proteins. These findings include previously unobserved relationships to single-particle microrheology and macroscopic results.
Heather Powell, Ph.D. (Advisor)
Peter Anderson, Ph.D. (Advisor)
Gregory Lafyatis, Ph.D. (Committee Member)
212 p.
Biomedical Research; Materials Science
microrheology; collagen; multi-particle; optical trap; laser tweezers

Recommended Citations

Citations

  • Gutschick, D. D. (2018). Characterization of Soft Gels with 2P Microrheology, a Novel, Active Paired-Particle Method [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534742722866439

    APA Style (7th edition)

  • Gutschick, David. Characterization of Soft Gels with 2P Microrheology, a Novel, Active Paired-Particle Method. 2018. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1534742722866439.

    MLA Style (8th edition)

  • Gutschick, David. "Characterization of Soft Gels with 2P Microrheology, a Novel, Active Paired-Particle Method." Doctoral dissertation, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1534742722866439

    Chicago Manual of Style (17th edition)

osu1534742722866439
167
© 2018, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.