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Design and Synthesis of Novel Bioactive Compounds for the Development of HIV-1 Allosteric Integrase Inhibitors, 20S Proteasome Inhibitors, and Anticancer Natural Product Derivatives

Wilson, Tyler Aron
http://rave.ohiolink.edu/etdc/view?acc_num=osu1565967461685907

Abstract Details

2019, Doctor of Philosophy, Ohio State University, Pharmaceutical Sciences.
Small molecules have undeniably played a crucial role in the development of new therapies for multiple disease states including HIV and cancer. The inspiration for these small molecule leads comes from various areas including previously established synthetic leads or natural products. Regardless of the origin or type of small molecule, synthetic access remains a challenging but important part of developing these compounds into potential drug candidates.
James Fuchs (Advisor)
Karl Werbovetz (Committee Member)
Liva Rakotondraibe (Committee Member)
461 p.
Chemistry; Pharmacy Sciences
HIV; Allosteric, Integrase, Proteasome

Recommended Citations

Citations

  • Wilson, T. A. (2019). Design and Synthesis of Novel Bioactive Compounds for the Development of HIV-1 Allosteric Integrase Inhibitors, 20S Proteasome Inhibitors, and Anticancer Natural Product Derivatives [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565967461685907

    APA Style (7th edition)

  • Wilson, Tyler. Design and Synthesis of Novel Bioactive Compounds for the Development of HIV-1 Allosteric Integrase Inhibitors, 20S Proteasome Inhibitors, and Anticancer Natural Product Derivatives. 2019. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1565967461685907.

    MLA Style (8th edition)

  • Wilson, Tyler. "Design and Synthesis of Novel Bioactive Compounds for the Development of HIV-1 Allosteric Integrase Inhibitors, 20S Proteasome Inhibitors, and Anticancer Natural Product Derivatives." Doctoral dissertation, Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565967461685907

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.