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Microparticulate Hydrogel Materials Towards Biomedical Applications

Niu, Ye
http://orcid.org/0000-0002-5825-8106
http://rave.ohiolink.edu/etdc/view?acc_num=osu1586094812805108

Abstract Details

2020, Doctor of Philosophy, Ohio State University, Mechanical Engineering.
Microparticulate hydrogel materials are widely used in many biomedical applications such as regenerative medicine, biosensing and target drug delivery due to their excellent biocompatibility, biodegradability, controllability, and mechanical softness. The geometric and viscoelastic properties of such particulate hydrogel materials can have significant variations during the synthesis processes that can limit their uses. To improve the efficacy of particulate hydrogel materials in respective applications, two routes can be explored. The first is to characterize the geometric and viscoelastic properties of such particulate hydrogel materials, screening out those with undesired properties before putting them into applications. The second is to improve the stability of the synthesis processes, achieving the desired properties with excellent uniformity. Current characterization and synthesis approaches suffer from low-throughput, inaccuracy, complicated systems, and instability. To address those problems, this dissertation also explored those two routes towards facilitating the efficacy of microparticulate hydrogel materials in their biomedical applications. This dissertation first introduces several continuous-flow microfluidic approaches that can simultaneously measure the geometric (overall size and shell thickness) and viscoelastic properties (elasticity and viscosity) of particulate hydrogel materials with high throughput and accuracy. Different from previous approaches, the approaches demonstrated in this dissertation show several better features such as accurate measurement results (considering the stress relaxation behavior of hydrogel materials), high throughput (up to ~2500 microparticle/min), stand-alone and simple systems (eliminating the complex high-speed optical systems). These approaches hold great potentials in certain applications such as geometric screening of core/shell microcapsules and point-of-care early-stage oral cancer screening applications. Besides characterizing the microparticles, the second part of this dissertation develops a simple and flexible technology for simultaneous synthesizing and on-demand positioning of particulate hydrogel materials using an oblique interface shearing (OIS) technique. Potential applications such as on-demand positioning of homogeneous microbeads with different or same sizes, and fabricating spatially gradient drug release assays by positioning core/shell microcapsules with different drug loads are demonstrated. This dissertation provides a powerful solution to overcome the limitations of the current characterization and synthesis approaches for particulate hydrogel materials. It is expected to facilitate the exploration of such particulate hydrogel materials in various biomedical applications.
Yi Zhao (Advisor)
Jonathan Song (Committee Member)
Ronald Xu (Committee Member)
Pierluigi (Enrico) Bonello (Committee Member)
163 p.
Biomedical Engineering; Mechanical Engineering
hydrogel; microfluidics; viscoelastic; microparticles;

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Citations

  • Niu, Y. (2020). Microparticulate Hydrogel Materials Towards Biomedical Applications [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586094812805108

    APA Style (7th edition)

  • Niu, Ye. Microparticulate Hydrogel Materials Towards Biomedical Applications. 2020. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1586094812805108.

    MLA Style (8th edition)

  • Niu, Ye. "Microparticulate Hydrogel Materials Towards Biomedical Applications." Doctoral dissertation, Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586094812805108

    Chicago Manual of Style (17th edition)

osu1586094812805108
93
© 2020, some rights reserved.Creative Commons License Microparticulate Hydrogel Materials Towards Biomedical Applications by Ye Niu is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.