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Master's thesis_Jingjie Du.pdf (4.04 MB)

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Gut microbiome and virome response to spinal cord injury

Du, Jingjie
http://rave.ohiolink.edu/etdc/view?acc_num=osu1589199990078058

Abstract Details

2020, Master of Science, Ohio State University, Microbiology.
The diversity and function of the human microbiome have been extensively studied over the last 10 years. Emerging evidence suggests that the gut microbiome plays an essential role in a wide range of human diseases, including acute, traumatic spinal cord injury (SCI). Previous work has characterized gut dysbiosis in SCI, correlating changes to clinical outcomes or other biomarkers. However, the study of the gut virome in health and disease remain largely unknown, because viruses lack universal marker genes for taxonomic assignment. This work represents the first time the gut virome has been characterized in SCI and provides the first look at potential functional changes in the gut microbiome in SCI at the level of gene loss. As with our previous work, we present a unique multi-level SCI model, allowing us to compare partially preserved sympathetic enteric enervation (T10) with a total loss of sympathetic enteric enervation (T4). Our results reveal level-specific patterns of gut dysbiosis, which may inform microbe-based predictions of severity and locomotor outcome in SCI. Further, this research is the first time that the viral and functional components of the gut microbiome have been characterized in SCI areas, which represent possible therapeutic targets for improving outcomes in SCI.
Matthew Sullivan (Advisor)
Phillip Popovich (Committee Member)
Virginia Rich (Committee Member)
108 p.
Microbiology
Spinal cord injury, gut microbiome, gut virome

Recommended Citations

Citations

  • Du, J. (2020). Gut microbiome and virome response to spinal cord injury [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1589199990078058

    APA Style (7th edition)

  • Du, Jingjie. Gut microbiome and virome response to spinal cord injury. 2020. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1589199990078058.

    MLA Style (8th edition)

  • Du, Jingjie. "Gut microbiome and virome response to spinal cord injury." Master's thesis, Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1589199990078058

    Chicago Manual of Style (17th edition)

osu1589199990078058
184
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This open access ETD is published by The Ohio State University and OhioLINK.