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Side Effects of 0.01% Atropine

Cyphers, Benjamin
http://rave.ohiolink.edu/etdc/view?acc_num=osu161701167574429

Abstract Details

2021, Master of Science, Ohio State University, Vision Science.
Introduction: High myopia decreases quality of life and puts patients at risk for vision loss. Low concentration atropine drops have been shown to slow the progression of myopia in children. High concentrations of atropine cause mydriasis and cycloplegia but 0.01% atropine seems to have a better side effect profile and less rebound after discontinuation. The purpose of this study is to completely document all potential side effects associated with 0.01% atropine drops. Methods: Measurements of visual acuity, phoria, pupil size, accommodation, reading speed, and intraocular pressure were taken before and after daily administration of 0.01% atropine drops for one week. A symptom survey was also administered at both visits. Ocular discomfort immediately after administering drops was measured with 0.01% atropine drops, artificial tear drops, and proparacaine drops to characterize the discomfort caused by 0.01% atropine drop administration. Results: A total of 31 subjects, age range 22 to 26 years, were e. After one week, photopic pupil size increased from 4.9 ± 0.8 mm to 5.1 ± 0.6 mm (p = 0.002). Intraocular pressure increased from 15.5 ± 2.9 mmHg to 17.0 ± 2.8 mmHg (p < 0.001). Reading speed increased from 173.4 + 31.5 wpm to 179.3 ± 31 wpm (p = 0.01). No other ocular measurements or survey responses changed significantly after drop administration. When asked if they would take low concentration atropine to delay the onset of nearsightedness, iii subjects replied with an average of 8.2 ± 2.1 on a scale of 1 to 10, 1 being "definitely not" and 10 being "definitely would." Proparacaine caused significantly more discomfort immediately after instillation compared to atropine and artificial tears, which were not significantly different from each other. After 5 seconds, atropine and proparacaine caused similar discomfort, but artificial tears caused significantly less discomfort than both. After 10 seconds, all three drops were significantly different from each other, with atropine causing the most discomfort and artificial tears causing the least. Discussion: Our results show that daily administration of low concentration atropine drops to slow the progression of myopia would be acceptable to patients and result in a very low risk profile.
Jeffrey Walline (Advisor)
Donald Mutti (Committee Member)
Melissa Bailey (Committee Member)
53 p.
Ophthalmology
atropine; myopia control; myopia management

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Citations

  • Cyphers, B. (2021). Side Effects of 0.01% Atropine [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu161701167574429

    APA Style (7th edition)

  • Cyphers, Benjamin. Side Effects of 0.01% Atropine. 2021. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu161701167574429.

    MLA Style (8th edition)

  • Cyphers, Benjamin. "Side Effects of 0.01% Atropine." Master's thesis, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu161701167574429

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.