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Effect of Prepartum Vaccination and Pen Change with an Acidogenic Diet on Lying Time, Metabolic Profile, and Immunity in Holstein Dairy Cows

Menichetti, Bernardo T
http://rave.ohiolink.edu/etdc/view?acc_num=osu1619023339384099

Abstract Details

2021, Doctor of Philosophy, Ohio State University, Comparative and Veterinary Medicine.
The overall objective of this study was to determine the effect of prepartum vaccination timing relative to pen change with an acidogenic diet on lying time (LT), metabolic profile (glucose, insulin-like growth factor-1 [IGF-1], fatty acids [FA], and calcium [Ca] status), and humoral immune response at calving (serum and colostrum IgG’s concentration) as well as the association of LT consistency measured as the coefficient of variation of LT with colostral G immunoglobulin (IgG) and cortisol concentrations in Holstein dairy cows. Therefore, the following three specific aims were aimed to accomplish our main objective above. Specific aim #1 (Chapter 3): To assess the effects of prepartum booster vaccination timing relative to pen change with an acidogenic diet on LT, energy status (glucose, IGF-1, and FA), urine pH, and serum Ca at calving in pregnant Holstein dairy cows. Vaccinating cows at 28 d prepartum, 7 d prior to a pen change and introduction of an acidogenic diet, did not affect LT but improved measures of energy and Ca status at calving compared to cows exposed to vaccination plus pen change at 21 d prepartum. This first specific aim shows the importance of vaccination timing relative to pen change on common changes in metabolism around the time of parturition. Specific aim #2 (Chapter 4): To assess the effect of prepartum vaccination timing relative to pen change with an acidogenic diet on colostral and serum IgG concentrations at calving. Vaccinating cows at 28 d prepartum, 7 d prior to pen change with an acidogenic diet improved colostral IgG concentrations at calving. Specific aim #3 (Chapter 5): To evaluate the association of a CV of LT within 7 d prior parturition with colostrum IgG and cortisol concentrations at calving. Findings from this specific aim revealed that reduced CV of LT was associated with increased colostrum IgG concentrations at calving, but CV of LT was not associated with colostrum cortisol. Overall, these findings suggest that the timing of prepartum vaccination relative to pen change with an acidogenic diet, as well as a more consistent prepartum LT (CV of LT), improved the metabolic and immunological status of cows at calving.
Gustavo Schuenemann (Advisor)
200 p.
Biology; Veterinary Services
prepartum vaccination, pen change, acidogenic diet, immunoglobulin, dairy cattle

Recommended Citations

Citations

  • Menichetti, B. T. (2021). Effect of Prepartum Vaccination and Pen Change with an Acidogenic Diet on Lying Time, Metabolic Profile, and Immunity in Holstein Dairy Cows [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619023339384099

    APA Style (7th edition)

  • Menichetti, Bernardo. Effect of Prepartum Vaccination and Pen Change with an Acidogenic Diet on Lying Time, Metabolic Profile, and Immunity in Holstein Dairy Cows. 2021. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1619023339384099.

    MLA Style (8th edition)

  • Menichetti, Bernardo. "Effect of Prepartum Vaccination and Pen Change with an Acidogenic Diet on Lying Time, Metabolic Profile, and Immunity in Holstein Dairy Cows." Doctoral dissertation, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619023339384099

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.
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