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Cellular Iron Homeostasis Mechanisms in Erythrocytes and Colon Cells

Teria, Rodney Santos, Jr.
http://orcid.org/0000-0002-3008-3260
http://rave.ohiolink.edu/etdc/view?acc_num=osu1620656407818459

Abstract Details

2021, Master of Mathematical Sciences, Ohio State University, Mathematical Sciences.
Cellular iron is important for various biological processes but can be cytotoxic in abundance, catalyzing free radicals from reactive oxygen species via the Fenton reaction. Consequently, proper maintenance or homeostasis of intracellular iron is critical for healthy cells. While many intracellular iron metabolism pathways are conserved across cell type within eukaryotes, there are cell-type-specific differences both in the iron metabolism network and in vulnerability to iron overload. Here we compare the iron metabolism networks for two cell types, colon cells and erythrocytes. We then apply a recently developed mathematical theory classifying mechanisms of homeostasis in terms of the structure of the underlying network. This analysis reveals very different homeostatic mechanisms supported by the iron metabolism networks of these two cell types. Notably, the mechanisms supported by the less vulnerable network are also the ones more commonly shared with other cell types. The implications of these findings provide new insights for intracellular iron homeostasis at the cell-type level.
Janet Best, PhD (Advisor)
Adriana Dawes, PhD (Committee Member)
46 p.
Biology; Mathematics
homeostasis; iron; input-output networks; iron overload;

Recommended Citations

Citations

  • Teria, Jr., R. S. (2021). Cellular Iron Homeostasis Mechanisms in Erythrocytes and Colon Cells [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1620656407818459

    APA Style (7th edition)

  • Teria, Jr., Rodney. Cellular Iron Homeostasis Mechanisms in Erythrocytes and Colon Cells. 2021. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1620656407818459.

    MLA Style (8th edition)

  • Teria, Jr., Rodney. "Cellular Iron Homeostasis Mechanisms in Erythrocytes and Colon Cells." Master's thesis, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1620656407818459

    Chicago Manual of Style (17th edition)

osu1620656407818459
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This open access ETD is published by The Ohio State University and OhioLINK.