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Full text release has been delayed at the author's request until August 09, 2026

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Characterizing the Role of Nucleoside Transporters in Blood Cell Formation and Drug Disposition

Persaud, Avinash K
http://rave.ohiolink.edu/etdc/view?acc_num=osu162671895910757

Abstract Details

2021, Doctor of Philosophy, Ohio State University, Pharmaceutical Sciences.
Nucleosides play essential roles in DNA and RNA synthesis, metabolism, signal transduction, and immune modulation. Multiple regulatory proteins work together to sustain optimal nucleoside concentrations required to meet physiological demands. However, the contribution of solute carrier (SLC) proteins that transport hydrophilic nucleosides across lipid bilayers is often overlooked as key regulators of nucleoside action. The two major families of SLC proteins that translocate nucleosides across cell membranes are equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs). Recently, variation in the transporter function and expression of these nucleoside transporters (NTs) were associated with defects in blood cell formation and drug disposition. Here, we systematically identified ENTs and CNTs that are essential for the successful differentiation and production of functional blood cells, and we highlight a critical role for nucleoside transporters in nucleoside analog disposition through the generation and characterization of novel transporter-deficient murine models. Results from these studies support the clinical evaluation of NTs mutational status and expression in patients with blood disorders, provide a rationale for stratifying patients receiving nucleoside drugs, and underscore novel treatment strategies that modulate NT expression to improve drug efficacy.
Govindarajan Rajgopal (Advisor)
Sharyn Baker (Committee Member)
Moray Campbell (Committee Member)
290 p.
Pharmaceuticals; Pharmacology; Pharmacy Sciences

Recommended Citations

Citations

  • Persaud, A. K. (2021). Characterizing the Role of Nucleoside Transporters in Blood Cell Formation and Drug Disposition [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu162671895910757

    APA Style (7th edition)

  • Persaud, Avinash. Characterizing the Role of Nucleoside Transporters in Blood Cell Formation and Drug Disposition. 2021. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu162671895910757.

    MLA Style (8th edition)

  • Persaud, Avinash. "Characterizing the Role of Nucleoside Transporters in Blood Cell Formation and Drug Disposition." Doctoral dissertation, Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu162671895910757

    Chicago Manual of Style (17th edition)

osu162671895910757
© 2021, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.