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Neurochemical Cytoarchitecture of the Primate Parabrachial Nucleus

Gehring, Bradley Brian
http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1461776675

Abstract Details

2016, Bachelor of Sciences, Ohio University, Biological Sciences.
We describe the distribution of calbindin (CAL), cholecystokinin (CCK), dynorphin (DYN), galanin (GAL), neurotensin (NT), somatostatin (SOM), and substance P (SP) immunoreactive elements in the primate parabrachial nucleus (PbN), a pontine structure with a crucial role in autonomic control. This study follows earlier work using calcitonin gene-related peptide (CGRP) as a marker for ascending visceral pathways in the human brain (de Lacalle & Saper, 2000). Our observations were made on horizontal sections through the brainstem from four neurologically normal human individuals and five male Cebus monkeys. Tissue was processed for immunocytochemistry using commercially available antibodies. Which revealed areas of dense peptide immunoreactivity in fibers, as well as in cell bodies. The extreme expansion of the superior cerebellar peduncle has altered the topographical organization of these pathways in the primate. However, using the peduncle as a marker, we found that similarities in the distribution of cell bodies and fibers remain conserved in some areas across species. The PbN of the Cebus monkey contained well defined external lateral and external medial subnuclei. The distribution of CAL-ir , CCK-ir, NT-ir, SOM-ir, and SP-ir elements were very similar in the human and monkey for the external lateral and external medial subnuclei, and DYN-ir elements were found in the external lateral PbN only in both species. GAL-ir elements were present in the central lateral PbN and dorsal medial PbN areas in both species. Our results contribute to define a neurochemical identity for different regions in the primate PbN, thus providing support to the delineation of physiological roles for the distinct subnuclei of this crucial visceral regulatory region.
Christine Griffin, Dr. (Advisor)
96 p.
Neurosciences
human; monkey; parabrachial nucleus; calbindin; cholesystekinin; dynorphin; galanin; neurotensin; somatostatin; substance P

Recommended Citations

Citations

  • Gehring, B. B. (2016). Neurochemical Cytoarchitecture of the Primate Parabrachial Nucleus [Undergraduate thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1461776675

    APA Style (7th edition)

  • Gehring, Bradley. Neurochemical Cytoarchitecture of the Primate Parabrachial Nucleus. 2016. Ohio University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1461776675.

    MLA Style (8th edition)

  • Gehring, Bradley. "Neurochemical Cytoarchitecture of the Primate Parabrachial Nucleus." Undergraduate thesis, Ohio University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1461776675

    Chicago Manual of Style (17th edition)

ouashonors1461776675
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© 2016, some rights reserved.Creative Commons License Neurochemical Cytoarchitecture of the Primate Parabrachial Nucleus by Bradley Brian Gehring is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Ohio University Art and Sciences Honors Theses and OhioLINK.