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p53, CLIC, AND THE JAK/STAT PATHWAY: INVESTIGATING THE LINK BETWEEN CANCER STRESSES AND CELL DEATH IN DROSOPHILA MELANOGASTER

Chang, Samantha J
http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1399820564

Abstract Details

2014, Bachelor of Science (BS), Ohio University, Biological Sciences.
Cancer is very prevalent in our society, and encompasses more than 100 different diseases. Additionally, each cancer can act distinctly, and current cancer therapies, such as chemotherapy and radiation, can lead to future complications. These facts implicate the need for new avenues of safer and more effective treatments. Oncogenic stresses are a hallmark characteristic of cancer, arising from the rapid growth and proliferation of cells. In response to these oncogenic stresses, the cells respond in a variety of ways, such as cell cycle arrest, DNA repair mechanisms, and cell death, in an attempt to overcome these stresses in and proliferate. Additionally, cancer is characterized by the activation of oncogenes and the loss of tumor-suppressor genes, which are involved in cell cycle arrest, as well as cell death. Therefore, in this project we investigated the link between cell death and cancer stresses by examining the interaction of p53, Clic, and the JAK/STAT pathway, all of which are known to be mutated in some cancers. The results presented in this thesis suggest that the activation of JAK/STAT pathway through the hopTum mutation creates a pro-apoptotic environment that likely stimulates p53 function. Furthermore, this stimulation is activating the canonical p53/apoptotic pathway, as well as a non-canonical p53 cell death pathway. Our results also implicate that Clic is acting in an anti-apoptotic manner.
Soichi Tanda (Advisor)
75 p.
Biology
p53; JAK; Clic; apoptosis; cancer; cell death; Drosophila melanogaster; oncogenic stress

Recommended Citations

Citations

  • Chang, S. J. (2014). p53, CLIC, AND THE JAK/STAT PATHWAY: INVESTIGATING THE LINK BETWEEN CANCER STRESSES AND CELL DEATH IN DROSOPHILA MELANOGASTER [Undergraduate thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1399820564

    APA Style (7th edition)

  • Chang, Samantha. p53, CLIC, AND THE JAK/STAT PATHWAY: INVESTIGATING THE LINK BETWEEN CANCER STRESSES AND CELL DEATH IN DROSOPHILA MELANOGASTER. 2014. Ohio University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1399820564.

    MLA Style (8th edition)

  • Chang, Samantha. "p53, CLIC, AND THE JAK/STAT PATHWAY: INVESTIGATING THE LINK BETWEEN CANCER STRESSES AND CELL DEATH IN DROSOPHILA MELANOGASTER." Undergraduate thesis, Ohio University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1399820564

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Ohio University Honors Tutorial College and OhioLINK.