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Morell Thesis 2023.pdf (1.43 MB)

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Therapeutic Effects of Cannabidiol in Diabetes Mellitus

Morell, Joseph Michael
http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1683195210392625

Abstract Details

2023, Bachelor of Science (BS), Ohio University, Translational Health.
Background: Diabetes mellitus is a collection of chronic diseases characterized by hyperglycemia, or high blood sugar. Chronic health complications can arise from this disease, including macrovascular complications such as cardiovascular disease that can result in myocardial infarction and/or stroke, microvascular complications including retinopathy, nephropathy, and neuropathy, as well as psychological complications such as depression, anxiety, and diabetes distress. Despite the existence of many effective glycemic control agents, rates of diabetes incidence and mortality continue to rise, prompting the investigation of novel, multi-action therapeutics. Cannabidiol (CBD) is a non-intoxicating phytocannabinoid derived from the Cannabis sativa (marijuana) plant that has widespread physiological effects, an excellent safety profile, and growing consumer interest within the US. Methods: A comprehensive, scoping review of the literature was conducted in order to organize and assess evidence for CBD's ability to manage, prevent, and or delay the onset of diabetes and diabetic complications. The research databases PubMed, Embase, Cochrane Library, and SCOPUS were searched. Results: A total of 1,324 articles were assessed against relevant inclusion and exclusion criteria, resulting in 40 included articles. The majority of included articles reported CBD improved glycemic measures associated with diabetes, yet this was not an overwhelming consensus. CBD showed mixed therapeutic effects in diabetic complications. This scoping review provides a broad review of studies with heterogenous designs and methods. Gaps in the scientific literature were discovered, including deficits in human in vivo research evaluating the therapeutic effects of CBD in diabetes and diabetic complications, as well as conflicting experimental results. Conclusions: More research, especially in diabetic human subjects, is needed to elucidate the therapeutic effects of CBD in diabetes and diabetic complications.
Cheryl Howe (Committee Chair)
Yuanjie Mao (Advisor)
68 p.
Alternative Medicine; Biomedical Research; Endocrinology
Cannabidiol, CBD, Diabetes, Diabetic Complications

Recommended Citations

Citations

  • Morell, J. M. (2023). Therapeutic Effects of Cannabidiol in Diabetes Mellitus [Undergraduate thesis, Ohio University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1683195210392625

    APA Style (7th edition)

  • Morell, Joseph. Therapeutic Effects of Cannabidiol in Diabetes Mellitus. 2023. Ohio University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1683195210392625.

    MLA Style (8th edition)

  • Morell, Joseph. "Therapeutic Effects of Cannabidiol in Diabetes Mellitus." Undergraduate thesis, Ohio University, 2023. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1683195210392625

    Chicago Manual of Style (17th edition)

ouhonors1683195210392625
119
© 2023, all rights reserved.
This open access ETD is published by Ohio University Honors Tutorial College and OhioLINK.