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Drug Design (STAT5 Modulators), Development (Glyceollin I) and Improvement (Esmolol Plus)

Reese, Michael D.
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1265033116

Abstract Details

2009, Master of Science in Medicinal Chemistry, University of Toledo, Medicinal Chemistry.
This thesis encompasses several different research activities that can contribute to advances within the pharmaceutical arena. The first part of my thesis describes synthetic work directed toward improving the clinical profile of a marketed drug called ‘esmolol’ by developing only its active enantiomer. The second part of the thesis describes my contributions toward the overall scale-up synthesis of a promising anticancer agent called ‘glyceollin I,’ which was undertaken in a team effort. The final part of the thesis describes my efforts to assemble an initial library of compounds that can be used to probe the STAT5 pathway for the potential inhibition of prostate cancer.
Paul Erhardt, Ph.D. (Advisor)
Jeffrey Sarver, Ph.D. (Committee Member)
L.M.V. Tillekeratne, Ph.D. (Committee Member)
75 p.
Chemistry; Organic Chemistry; Pharmaceuticals
Esmolol; Brevibloc; Glyceollins; Glyceollin I; STAT5

Recommended Citations

Citations

  • Reese, M. D. (2009). Drug Design (STAT5 Modulators), Development (Glyceollin I) and Improvement (Esmolol Plus) [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1265033116

    APA Style (7th edition)

  • Reese, Michael. Drug Design (STAT5 Modulators), Development (Glyceollin I) and Improvement (Esmolol Plus). 2009. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1265033116.

    MLA Style (8th edition)

  • Reese, Michael. "Drug Design (STAT5 Modulators), Development (Glyceollin I) and Improvement (Esmolol Plus)." Master's thesis, University of Toledo, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1265033116

    Chicago Manual of Style (17th edition)

toledo1265033116
869
© 2009, all rights reserved.
This open access ETD is published by University of Toledo and OhioLINK.