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Modeling of Controlled Drug Delivery from a Chitosan Microparticle

Alipourasiabi, Niloofar
http://orcid.org/0000-0002-2852-5728
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470352546

Abstract Details

2016, Master of Science, University of Toledo, Chemical Engineering.
Nowadays, advanced controlled drug delivery systems have been attracted the pharmaceutical research studies. As several experiments have to be done for pharmaceutical approaches, mathematical modeling becomes important. Mathematical modeling of drug release provides better understanding of controlled drug delivery system and would help to optimize the system without huge number of expensive experiments. Diffusion is the predominant transport phenomena of the drug delivery systems. Therefore, optimizing the parameters related to diffusional mass transport, such as diffusion coefficient and porosity, would be the essential key to get better controlled drug release profile. One of the challenges of controlled drug delivery systems is the initial burst, which decreases the effective lifetime of drug and would cause toxicity. This challenge has been solved by using a coating layer to control the drug release. Regarding to this issue, promising modeling results have been shown in this study and all the modeling data have been fitted with available experimental set of data. The mathematical modeling results in a partial differential equation. The analytical solution for the simplified equation is provided in this study. However, the boundary condition for the outer layer is complicated and the solution for the real problem would be available by using numerical methods. Finite difference method provided the numerical solution to the real problem and MATLAB software facilitate the process of solving the equation numerically.
Arunan Nadarajah, Dr. (Committee Chair)
Lidia Rodriguez, Dr. (Committee Member)
Maria Coleman, Dr. (Committee Member)
Biomedical Engineering; Chemical Engineering

Recommended Citations

Citations

  • Alipourasiabi, N. (2016). Modeling of Controlled Drug Delivery from a Chitosan Microparticle [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470352546

    APA Style (7th edition)

  • Alipourasiabi, Niloofar. Modeling of Controlled Drug Delivery from a Chitosan Microparticle. 2016. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470352546.

    MLA Style (8th edition)

  • Alipourasiabi, Niloofar. "Modeling of Controlled Drug Delivery from a Chitosan Microparticle." Master's thesis, University of Toledo, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470352546

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Toledo and OhioLINK.