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Magnesium-based Biomedical Implants: Towards a Mathematical Model for Degradation and Design

Amerinatanzi, Amirhesam
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1533048186717968

Abstract Details

2018, Doctor of Philosophy, University of Toledo, Biomedical Engineering.
Magnesium (Mg)-based alloys can dissolve in the physiological environments. This property makes these biomaterials attractive for implants. Many implants and medical devices should ideally be removed after a certain period of time. The secondary procedures of removal however are costly and not desirable. Moreover, these alloys present other beneficial characteristics such as biocompatibility, low specific density (1.74-2.0 g/cm3), and close to the bone stiffness. This last property could be beneficial in addressing the stress shielding as an adverse effect of metallic implants. Stress shielding occurs once the high stiff implant carries a significant portion of mechanical load during the post-healing period and shields the surrounding bone from carrying enough load, which in turn results in bone resorption in the areas of low mechanical load. Despite of the current interest in bioresorbale medical implants, there is still a need to model the corrosion behavior of these alloys in the body. The primary objective of this research is therefore to develop a model to capture the effect of pitting corrosion as well as stress corrosion in both compression and tension. Another objective of this study is to apply the model to evaluate the performance of an implant used in reconstructing the mandible. In developing the model, a finite element model is adopted that includes the chemistry of corrosion as well as the effect of stress. Previously conducted corrosion experiments will be combined with new experiments to capture the effect of stress in order to find the parameters of the model. This calibrated and validated model will be applied to simulate the degradation of an Mg-based mandibular implant for reconstructive surgery. The simulation will predict the duration of integrity of the implant during which is will act as a load bearing element. It is expected that the findings of this research will serve as a modeling and therefore an optimization engine for designing Mg-based implant to satisfy the load-carrying requirements as well as the degradation requirements.
Mohammad Elahinia (Committee Chair)
Matthew Franchetti (Committee Member)
Efstratios Nikolaidis (Committee Member)
Hassan Hassabelnaby (Committee Member)
Nicholas Horen (Committee Member)
136 p.
Biomedical Engineering; Mechanical Engineering
Biodegradable alloys; Magnesium alloy; Finite element modeling; Corrosion model

Recommended Citations

Citations

  • Amerinatanzi, A. (2018). Magnesium-based Biomedical Implants: Towards a Mathematical Model for Degradation and Design [Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1533048186717968

    APA Style (7th edition)

  • Amerinatanzi, Amirhesam. Magnesium-based Biomedical Implants: Towards a Mathematical Model for Degradation and Design. 2018. University of Toledo, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=toledo1533048186717968.

    MLA Style (8th edition)

  • Amerinatanzi, Amirhesam. "Magnesium-based Biomedical Implants: Towards a Mathematical Model for Degradation and Design." Doctoral dissertation, University of Toledo, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1533048186717968

    Chicago Manual of Style (17th edition)

toledo1533048186717968
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This open access ETD is published by University of Toledo and OhioLINK.