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BLOOD GENOMIC FINGERPRINTS OF NEUROLOGICAL DISEASES - MICROARRAY STUDIES

TANG, YANG
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1035831350

Abstract Details

2002, PhD, University of Cincinnati, Medicine : Interdisciplinary (Medical Science Scholars, Neuroscience).
Gene expression profiling has the power to sensitively reflect a myriad of biological states and perturbations. This is highlighted by the recent progress in molecular classification of various cancers using DNA microarray technology. However, the application of this technology in studying most other human diseases is likely to be slow because of the paucity of biopsy and postmortem samples. The studies presented here sought to determine whether global expression profiling of blood cells could provide peripheral markers for diseases or phenotypes that do not involve the hematological system. This hypothesis was addressed by the following experiments. Firstly, rat models of brain ischemia, intracerebral hemorrhage, seizure, hypoglycemia and hypoxia were used to investigate whether each disease model produced characteristic blood genomic expression fingerprints. At the same time, brain gene expression changes were also surveyed to study the mechanisms of brain injuries associated with each condition. Secondly, rat models were used to determine whether there is a common blood genomic expression pattern that correlates with the occurrence of various neuronal injuries. Finally, neurofibromatosis type 1 was used as a test case to examine whether blood expression profiling is capable of diagnosing clinical diseases. The effects of common confounding factors - age and gender - on blood genomics were also characterized. These results were consistent with the suggestion that diseases and phenotypes may produce unique expression signatures in blood cells and blood expression profiling can be used in diagnostic, mechanistic, and therapeutic assessment of these disease states.
Dr. Frank R. Sharp (Advisor)
176 p.
Biology, Neuroscience
blood; white cell; genomics; microarray; gene expression profiling

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Citations

  • TANG, Y. (2002). BLOOD GENOMIC FINGERPRINTS OF NEUROLOGICAL DISEASES - MICROARRAY STUDIES [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1035831350

    APA Style (7th edition)

  • TANG, YANG. BLOOD GENOMIC FINGERPRINTS OF NEUROLOGICAL DISEASES - MICROARRAY STUDIES. 2002. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1035831350.

    MLA Style (8th edition)

  • TANG, YANG. "BLOOD GENOMIC FINGERPRINTS OF NEUROLOGICAL DISEASES - MICROARRAY STUDIES." Doctoral dissertation, University of Cincinnati, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1035831350

    Chicago Manual of Style (17th edition)

ucin1035831350
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© 2002, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.