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Automated Human Pancreatic Islet Isolation System for Islet Transplantation in Patients with Type-i Insulin Dependent Diabetes Mellitus

Bakshi, Vishwas J.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1078278715

Abstract Details

2004, MS, University of Cincinnati, Engineering : Electrical Engineering.
Insulin Dependent Diabetes Mellitus is a leading cause of death not only here in the United states, but all over the world. The number of people afflicted by this disease is growing continuously. Pancreatic Human Islet cell Transplantation in patients with Type-I Insulin Dependent Diabetes Mellitus has been seen as a promising method of treatment, although it is now in a very fledgling state. In a recent effort reported by Dr. Jonathan Lakey and his team at University of Alberta, Edmonton Canada, Insulin independence and normal glucose metabolism was achieved for seven out of seven patients with Type-I Insulin Dependent Diabetes. University of Cincinnati’s Islet transplant program is one of the six programs in the United States approved to perform Islet cell Transplantation and only center in the state of Ohio. The long term insulin independence rate is still low for Human Islet transplantations. There are several reasons for this low rate including islet isolation methodology. It was thought that a systematic data of all parameters responsible for the outcome of the Islet Isolation procedure, if collected and analyzed, might provide a significant insight into the present method of isolation. Thus, the Islet transplant center at University of Cincinnati began to engineer and built a DAQ based Islet Isolation system to perform this intricate procedure. This complex isolation control system consists of several sensors, digital valves, computer interfacable devices and centralized Data Acquisition system. The LabVIEW software developed for this purpose is required to be highly reliable since a single failure during the isolation process could be fatal. The central DAQ system not only monitors and runs the complete process but also collects large amount of parameter data for further analysis. This large pool of collected data will definitely help in process standardization and process characterization which will lead to process optimization in the longer run. So far, several Islet transplantations have been performed using this system. A database is being generated for these transplantations and it is still growing. Collection and analysis of the data is a continuous and ongoing process. Researchers will continue to dig into the data and try to explore useful results. Let’s hope that the Islet cell Transplantation treatment may prove to be an ultimate cure to the deadly disease in near future.
Dr. Arthur Helmicki (Advisor)
203 p.
Islets; Pancreas; Isolation; Diabetes

Recommended Citations

Citations

  • Bakshi, V. J. (2004). Automated Human Pancreatic Islet Isolation System for Islet Transplantation in Patients with Type-i Insulin Dependent Diabetes Mellitus [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1078278715

    APA Style (7th edition)

  • Bakshi, Vishwas. Automated Human Pancreatic Islet Isolation System for Islet Transplantation in Patients with Type-i Insulin Dependent Diabetes Mellitus. 2004. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1078278715.

    MLA Style (8th edition)

  • Bakshi, Vishwas. "Automated Human Pancreatic Islet Isolation System for Islet Transplantation in Patients with Type-i Insulin Dependent Diabetes Mellitus." Master's thesis, University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1078278715

    Chicago Manual of Style (17th edition)

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This open access ETD is published by University of Cincinnati and OhioLINK.