The goal of this document is a paleopathological case study of one skeleton in the study collection at the University of Cincinnati (Individual H). Complete documentation of the individual included determining sex of the individual, assessing age at death, measurement of all long bones to assess size asymmetry, and cataloging all pathological characteristics through description and photography. The individual was determined to have been afflicted, during life, by an undifferentiated seronegative spondyloarthropathy (ankylosing spondylitis, psoriatic arthritis, Reiter’s syndrome). Differential diagnosis included comparison of characteristics seen on Individual H, to those associated with diffuse idiopathic skeletal hyperostosis.