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Central Nervous System Associations in Neurofibromatosis Type 1

Lamvik, Kate K.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179426618

Abstract Details

2007, MS, University of Cincinnati, Allied Health Sciences : Genetic Counseling.
Neurofibromatosis type 1 (NF1) frequently involves the central nervous system (CNS), but there is extreme variability in the expression of CNS complications, even within families with the same causative mutation. It has been proposed, but not proven, that CNS complications tend to cluster within individuals with NF1. We conducted a retrospective medical record review to determine if CNS abnormalities occur more frequently in individuals with NF1 who have an optic pathway glioma (OPG). Seventy-two (72) subjects with OPG and 189 without OPG were screened for CNS complications. OPGs were found to be associated with a diagnosis of additional CNS tumors and T2 hyperintensities, supporting a difference in CNS complications manifested by patients who develop OPG versus those who do not. Additional understanding of the biology of brain lesions in NF1 is necessary to further elucidate why patients with OPG are more likely to develop additional CNS lesions.
Dr. Elizabeth Schorry (Advisor)
24 p.
neurofibromatosis type 1 (NF1); optic pathway glioma (OPG); central nervous system (CNS)

Recommended Citations

Citations

  • Lamvik, K. K. (2007). Central Nervous System Associations in Neurofibromatosis Type 1 [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179426618

    APA Style (7th edition)

  • Lamvik, Kate. Central Nervous System Associations in Neurofibromatosis Type 1. 2007. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179426618.

    MLA Style (8th edition)

  • Lamvik, Kate. "Central Nervous System Associations in Neurofibromatosis Type 1." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1179426618

    Chicago Manual of Style (17th edition)

ucin1179426618
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© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.