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ucin1186037082.pdf (537.42 KB)
ETD Abstract Container
Abstract Header
Natural History of Allergic Sensitization in High-Risk Infants
Author Info
Anderson, Lisa N.
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186037082
Abstract Details
Year and Degree
2007, MS, University of Cincinnati, Medicine : Environmental Health.
Abstract
Objectives: Characterize the natural history of allergic sensitization and compare three definitions of skin prick test (SPT) positivity in infants born to an atopic parent. Study Design: Secondary data analysis of a prospective, high-risk birth cohort. Results: In a cohort of 477 infants, food allergen sensitization decreased from 11.7% at 12 months to 8.6% at 24 months while aeroallergen sensitization increased from 15.9% to 34.0%. Individual food allergen and aeroallergen persistence rates ranged from 0-55.6% but overall aeroallergen sensitization persisted at 61.8%. There was no statistical difference between the three SPT positivity definitions. Conclusions: Food allergen and aeroallergen sensitization begin in infancy. Although individual allergen sensitization was largely transient, overall aeroallergen sensitization persisted at 24 months. High-risk infants should be screened using the standard definition of a positive SPT to identify those at increased risk for the development of allergic disease.
Committee
Dr. James Lockey (Advisor)
Pages
24 p.
Keywords
Infants
;
Allergy
;
Sensitization
;
Allergy Testing
;
Skin Prick Test
;
Prevalence
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Citations
Anderson, L. N. (2007).
Natural History of Allergic Sensitization in High-Risk Infants
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186037082
APA Style (7th edition)
Anderson, Lisa.
Natural History of Allergic Sensitization in High-Risk Infants.
2007. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186037082.
MLA Style (8th edition)
Anderson, Lisa. "Natural History of Allergic Sensitization in High-Risk Infants." Master's thesis, University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186037082
Chicago Manual of Style (17th edition)
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Document number:
ucin1186037082
Download Count:
452
Copyright Info
© 2007, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.