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Outcomes and complications of fundoplication in children with cystic fibrosis

BOESCH, RICHARD PAUL
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204839634

Abstract Details

2008, MS, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Purpose: Children with cystic fibrosis (CF) have a high prevalence of gastroesophageal reflux disease (GERD). As GERD is associated with chronic respiratory symptoms and feeding problems, fundoplication is often performed in children with CF. Although the outcomes of fundoplication have been described across diverse pediatric groups, there is no published experience with CF. Methods: The records of 25 children with CF who underwent fundoplication in our center were reviewed. Data was collected regarding symptoms diagnostic testing, and complications related to fundoplication. Nutritional parameters and pulmonary function were compared before and after fundoplication. Results: There was no mortality associated with fundoplication but 12% had complications that required a subsequent surgical procedure. While 28% were able to discontinue their anti-reflux medications 48% developed symptoms of recurrent GERD. Overall there was no change in BMI, BMI percentile, or FEV1 slope following fundoplication. Children who had an FEV1 <60% predicted at the time of fundoplication exhibited an improvement in FEV1 slope compared to those with FEV1 >or = 60% (+5.3%/year vs. -8.6%/year, P=0.004). Conclusion: The complication rate of fundoplication is similar to what has been reported in large series' in children without CF. There is a high rate of recurrent GERD and little apparent benefit for either nutritional or pulmonary outcomes. The observed difference on FEV1 slope, in those with moderate-severe vs. mild lung disease, highlights the need to thoroughly evaluate the role of fundoplication in children with CF.
Dr. James Heubi (Advisor)
18 p.
fundoplication; cystic fibrosis; pulmonary function; nutrition

Recommended Citations

Citations

  • BOESCH, R. P. (2008). Outcomes and complications of fundoplication in children with cystic fibrosis [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204839634

    APA Style (7th edition)

  • BOESCH, RICHARD. Outcomes and complications of fundoplication in children with cystic fibrosis. 2008. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204839634.

    MLA Style (8th edition)

  • BOESCH, RICHARD. "Outcomes and complications of fundoplication in children with cystic fibrosis." Master's thesis, University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204839634

    Chicago Manual of Style (17th edition)

ucin1204839634
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© 2008, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.