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Genetic and Environmental Factors Influencing Wheezing in African Americans

LADEINDE, OYEBOLA O.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212172434

Abstract Details

2008, MS, University of Cincinnati, Medicine : Epidemiology (Environmental Health).
Objectives To determine whether genetic variants in the interleukin 4 (IL-4) and interleukin 13 (IL-13) genes influence recurrent wheezing in African American children and if these effects are modified by exposure to diesel exhaust particles (DEP), environmental tobacco smoke (ETS) and sensitization to allergens.Study Design A birth cohort of 643 children was evaluated annually by a questionnaire, physical examination, skin prick testing and buccal swabbing to obtain DNA samples. The relationship of ETS and DEP exposure, sensitization and genotype with the outcome of recurrent wheezing was analyzed. Results The prevalence of sensitization was 44.4% and recurrent wheezing was 16.4% at the third year visit. The odds of recurrent wheezing in African American children was significantly increased when they were sensitized to the aeroallergens; meadow fescue, red cedar, ragweed, penicillium, cockroach and cat. Conclusions In African American children with a family history of sensitization, exposure to red cedar, ragweed, penicillium, cockroach and cat increases the odds of recurrent wheezing.
Erin Haynes, Dr.P.H (Committee Chair)
39 p.

Recommended Citations

Citations

  • LADEINDE, O. O. (2008). Genetic and Environmental Factors Influencing Wheezing in African Americans [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212172434

    APA Style (7th edition)

  • LADEINDE, OYEBOLA. Genetic and Environmental Factors Influencing Wheezing in African Americans. 2008. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212172434.

    MLA Style (8th edition)

  • LADEINDE, OYEBOLA. "Genetic and Environmental Factors Influencing Wheezing in African Americans." Master's thesis, University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212172434

    Chicago Manual of Style (17th edition)

ucin1212172434
256
© 2008, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.