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Functions of Glypicans in Cell Signaling during Drosophila Development

Yan, Dong
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1239036587

Abstract Details

2009, PhD, University of Cincinnati, Medicine : Molecular and Developmental Biology.
Heparan sulfate proteoglycans (HSPGs) are cell-surface and extracellular matrix macromolecules that comprise a core protein to which a number of heparan sulfate (HS) glycosaminoglycan (GAG) chains are attached. Current evidence suggests that HSPGs participate in many different signaling pathways during development. However, it is largely unknown what specific HSPG molecules are involved in these processes. My work demonstrates that two Drosophila glypicans, Dally and Dally-like (Dlp), are the major HSPGs involved in Wg, Hh and FGF signaling. Furthermore, I analyzed the mechanisms of HSPG function in different signaling pathways by combining genetic, molecular and biochemical experiments. My work argues that much of the specific activities of Dlp in Hh and Wg signaling come from its core protein, rather than the attached HS GAG chains. Importantly, the new results from my studies allowed me to propose a novel model to explain the biphasic activity of Dlp in Wg morphogen signaling. Such a biphasic co-receptor is likely a general component in other morphogen systems, because I also found that another Hh co-receptor, Inteference hedgehog (Ihog), also has biphasic activity in Hh morphogen signaling. Thus, the dissertation work will shed light on the mechanisms of how the morphogen system is organized at the level of ligand binding.
Xinhua Lin, PhD (Committee Chair)
Iain Cartwright, PhD (Committee Member)
Janet Heasman, PhD (Committee Member)
Richard Lang, PhD (Committee Member)
Jun Ma, PhD (Committee Member)
208 p.
Biology; Genetics; Molecular Biology
Drosophila; development; signaling; HSPG; wnt; hedgehog; fgf

Recommended Citations

Citations

  • Yan, D. (2009). Functions of Glypicans in Cell Signaling during Drosophila Development [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1239036587

    APA Style (7th edition)

  • Yan, Dong. Functions of Glypicans in Cell Signaling during Drosophila Development. 2009. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1239036587.

    MLA Style (8th edition)

  • Yan, Dong. "Functions of Glypicans in Cell Signaling during Drosophila Development." Doctoral dissertation, University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1239036587

    Chicago Manual of Style (17th edition)

ucin1239036587
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© 2009, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.