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A Nonlinear Mixed Modeling Method to Analyze Allergen Assay Data and the Effects of Exposures Two Indoor Aeroallergens During Infancy on Children at Age Three: The CCAAPS Cohort

Liang, Juan
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1245413088

Abstract Details

2009, PhD, University of Cincinnati, Medicine : Environmental Health.
In chapter II, a nonlinear mixed modeling method is used to analyze immunoassay data. First, a nonlinear mixed four parameter logistic model is used to estimate the concentration-response relationship in the standard samples. Second, sample concentrations are calibrated by using the estimated relationships from standard samples. This nonlinear mixed modeling method is applied on allergens sample data in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS). It provides wider detection ranges than a log-log linear modeling method. More samples with low/high concentrations are estimated. In chapter III, the estimated home cat and dust mite allergen concentrations from samples which were collected at the first year of child’s age are used to explore the exposure-response relationships of two home aeroallergens at age one and three clinical outcomes at age three. Higher levels of dust mite allergen concentration are found to be a risk factor to develop persistent wheezing at age three and to be protective to develop SPT positivity to cat allergen at age three. African American children and non-African American children are observed having disproportionally high prevalence rates of persistent wheezing and SPT positivity at age three and also several demographic characteristics. From public health perspective, physicians and parents should be aware of these findings in order to improve asthma management and patient care.
Paul Succop (Committee Chair)
Linda Levin (Advisor)
Grace LeMasters (Committee Member)
David Berstein (Committee Member)
M.B Rao (Committee Member)
Ralph Buncher (Committee Member)
Immunology; Mathematics; Statistics
Nonlinear; Immunoassay; Allergen; Allergy;

Recommended Citations

Citations

  • Liang, J. (2009). A Nonlinear Mixed Modeling Method to Analyze Allergen Assay Data and the Effects of Exposures Two Indoor Aeroallergens During Infancy on Children at Age Three: The CCAAPS Cohort [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1245413088

    APA Style (7th edition)

  • Liang, Juan. A Nonlinear Mixed Modeling Method to Analyze Allergen Assay Data and the Effects of Exposures Two Indoor Aeroallergens During Infancy on Children at Age Three: The CCAAPS Cohort. 2009. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1245413088.

    MLA Style (8th edition)

  • Liang, Juan. "A Nonlinear Mixed Modeling Method to Analyze Allergen Assay Data and the Effects of Exposures Two Indoor Aeroallergens During Infancy on Children at Age Three: The CCAAPS Cohort." Doctoral dissertation, University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1245413088

    Chicago Manual of Style (17th edition)

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© 2009, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.