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Applications of Electrochemical Impedance Spectroscopy in In Vivo Corrosion Monitoring and Tissue Discrimination

Williams, Brian J.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311605422

Abstract Details

2011, MS, University of Cincinnati, Engineering and Applied Science: Mechanical Engineering.
This thesis summarizes work conducted in the Nanoworld lab at the University of Cincinnati studying the application of electrochemical impedance spectroscopy to provide real time data on corrosion and biofouling of electrodes implanted in live mice as well as the application of electrochemical impedance spectroscopy (EIS) for tissue discrimination. The Nanoworld lab is a member of the NSF ERC for Revolutionizing Metallic Biomaterials (ERC-RMB), where many groups are developing new magnesium-based materials and coatings for implanted devices. In vitro experimentation is inadequate to simulate the complexity of the target human tissue environment. In vivo experimentation conducted to date provides limited end point data by studying the chemical composition, mass, and other properties only at the end of the experiment. This paper discusses the development of techniques to monitor corrosion in real time by EIS, the implementation of this technique in mice, and the development of CNT based thread as an alternative to copper wire for use in this line of experimentation. Experiments are conducted in 4 different mice, and important phenomena relevant to the state of an implanted electrode are identified. The direct electrical connection to the implants required to collect this data provide the potential to not only characterize corrosion rates but also control the corrosion rate by the application of cathodic protection. Experiments are conducted and described in this document demonstrating this potential. Electrochemical impedance spectroscopy also provides a means to characterize tissue with a remarkable level of discrimination. Several groups have conducted research demonstrating the ability to use EIS to discriminate between cancerous tissue and healthy tissue in several tissue types. Lung surgeons at the University of Cincinnati have expressed significant interest in the potential for the application of this technique to differentiate between benign lung nodules and malignant tumors. This document describes the development of techniques and equipment to characterize tissue via EIS and describes preliminary work analyzing cancerous tissue.
Mark Schulz, PhD (Committee Chair)
Vesselin Shanov, PhD (Committee Member)
David Thompson, PhD (Committee Member)
113 p.
Mechanics
electrochemical; impedance; spectroscopy; corrosion; monitoring

Recommended Citations

Citations

  • Williams, B. J. (2011). Applications of Electrochemical Impedance Spectroscopy in In Vivo Corrosion Monitoring and Tissue Discrimination [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311605422

    APA Style (7th edition)

  • Williams, Brian. Applications of Electrochemical Impedance Spectroscopy in In Vivo Corrosion Monitoring and Tissue Discrimination. 2011. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311605422.

    MLA Style (8th edition)

  • Williams, Brian. "Applications of Electrochemical Impedance Spectroscopy in In Vivo Corrosion Monitoring and Tissue Discrimination." Master's thesis, University of Cincinnati, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311605422

    Chicago Manual of Style (17th edition)

ucin1311605422
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© 2011, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.