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Towards the development of rotaxanes with two functional blocking groups

Deodhar, Bhushan S.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311690891

Abstract Details

2011, MS, University of Cincinnati, Arts and Sciences: Chemistry.
Host-Rotaxanes function exceptionally well as cellular transport agents. Transport is mainly attributed to Host-rotaxane architecture, which consists of cyclophane pocket, DB24C8 wheel, and axle. The wheel needs to freely move along the axle. To function as a therapeutic device, however, a method to target cells is necessary. We propose that attaching a switch onto the wheel through an imine bond will control the motion of the wheel and enable the transporter to be turned on in acidic environments and turned off in basic environments. Human Body consists of wide range of pH values, which gives us a simple method to target various tissues or cell types. The first chapter describes the synthesis and characterization of Host-rotaxanes possessing an imine functionality. The second chapter will mainly deal with work involved in synthesis of novel Coumarin containing Host-rotaxanes. Coumarin derivatized rotaxanes will be used to determine the intracellular location of the rotaxane in the cells. The location can be monitored easily by observing coumarin’s fluorescence in the cells and can also be easily quantified by using methods such as flow cytometry. The future scope of the thesis and its development are discussed and recommendations are made.
David Smithrud, PhD (Committee Chair)
James Mack, PhD (Committee Member)
46 p.
Organic Chemistry
rotaxane; imine switch

Recommended Citations

Citations

  • Deodhar, B. S. (2011). Towards the development of rotaxanes with two functional blocking groups [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311690891

    APA Style (7th edition)

  • Deodhar, Bhushan. Towards the development of rotaxanes with two functional blocking groups. 2011. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311690891.

    MLA Style (8th edition)

  • Deodhar, Bhushan. "Towards the development of rotaxanes with two functional blocking groups." Master's thesis, University of Cincinnati, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311690891

    Chicago Manual of Style (17th edition)

ucin1311690891
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© 2011, some rights reserved.Creative Commons License Towards the development of rotaxanes with two functional blocking groups by Bhushan S. Deodhar is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.