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Regulation of Vascular Patterning by Macrophages and Microglia

Stefater III, James
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321367701

Abstract Details

2011, PhD, University of Cincinnati, Medicine: Molecular and Developmental Biology.
Myeloid cells are a feature of most tissues. Recently, it has become clear that myeloid cells do much more than simply protect the host from foreign invaders. In the work presented here, myeloid cells (including macrophages and microglia) are shown to regulate blood vessel patterning, a function quite distinct from their role in innate immunity. Specifically, retinal myeloid cells (RMCs) are shown to produce non-canonical Wnt ligands as a means to suppress blood vessel branching in the retina. In response to these non-canonical Wnt ligands, RMCs secrete Flt1, a naturally occurring inhibitor of vascular endothelial growth factor (VEGF). This signaling cascade is not limited to the retina. In wound assays of repair and regeneration, myeloid cells are shown to regulate blood vessel patterning in a similar way. These findings indicate that resident myeloid cells can use a non-canonical, Wnt-Flt1 pathway to suppress angiogenic branching in development and disease. This work, coupled with the emerging work of other laboratories, lays the groundwork for a new way of thinking about the immune system.
Richard Lang, PhD (Committee Chair)
Rashmi Hegde, PhD (Committee Member)
Jeffrey Pollard, PhD (Committee Member)
Christopher Karp, MD (Committee Member)
Saulius Sumanas, PhD (Committee Member)
Jeffrey Whitsett, MD (Committee Member)
125 p.
Molecular Biology

Recommended Citations

Citations

  • Stefater III, J. (2011). Regulation of Vascular Patterning by Macrophages and Microglia [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321367701

    APA Style (7th edition)

  • Stefater III, James. Regulation of Vascular Patterning by Macrophages and Microglia. 2011. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321367701.

    MLA Style (8th edition)

  • Stefater III, James. "Regulation of Vascular Patterning by Macrophages and Microglia." Doctoral dissertation, University of Cincinnati, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1321367701

    Chicago Manual of Style (17th edition)

ucin1321367701
204
© 2011, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.