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STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH

Tesak, Jennifer Lynn
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335402166

Abstract Details

2012, MS, University of Cincinnati, Arts and Sciences: Chemistry.
The exploitation of the copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has contributed to drug discovery due to the high degree of dependability, efficiency, specificity and biocompatibility of the reactions and products. Using this well-known click chemistry reaction, a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester to 4-azido-2,6-difluorophenol acetate. Characterizations of these materials were done using 1HNMR, 13CNMR, liquid chromatography mass spectrometry, and infrared spectroscopy.
Richard Taylor, PhD (Advisor)
Benjamin Gung, PhD (Committee Member)
Scott Hartley, PhD (Committee Chair)
David Tierney, PhD (Committee Member)
44 p.
Chemistry
click chemistry; apoptosis inhibitor Q-VD-OPh; NSAID

Recommended Citations

Citations

  • Tesak, J. L. (2012). STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335402166

    APA Style (7th edition)

  • Tesak, Jennifer. STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH. 2012. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335402166.

    MLA Style (8th edition)

  • Tesak, Jennifer. "STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH." Master's thesis, University of Cincinnati, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335402166

    Chicago Manual of Style (17th edition)

ucin1335402166
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© 2012, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.