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Plant-Based Compound Treatment of Hypercholesterolemia in the Zebrafish

Littleton, Robert M.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1355501728

Abstract Details

2012, PhD, University of Cincinnati, Medicine: Systems Biology and Physiology.
This work is focused on developing a zebrafish model system to test the ability of natural products to treat hypercholesterolemia and its peripheral cardiovascular consequences. In this endeavor, tools are developed and utilized to test the efficacy of the medicinal plant hawthorn (Crataegus laevigata) in treating lipid disorders, with emphasis on those ailments pertaining to cardiovascular health. Among these tools is a high-throughput automated antihypercholesterolemia screen. Complementing the utility of this screen is an automated algorithm for rapidly analyzing cardiodynamic data. This is the first time that the antihypercholesterolemic effects of the hawthorn plant have been quantified in the same experimental paradigm as the plant’s cardiotonic effects. Whereas previous studies have concentrated on a single aspect of hawthorn’s effects, such as testing its ability to effect cardiac cell inotropic states by measuring calcium transience in cardiac cell culture, the perspective utilized in this work lends insight into its potential to treat multifaceted diseases. Being closer to the whole body consequences of a disease such as hypercholesterolemia, testing in a paradigm that replicates human disease has the potential for a significant impact on human health.
Jay Hove, Ph.D. (Committee Chair)
David Hui, Ph.D. (Committee Member)
John Lorenz, Ph.D. (Committee Member)
Richard Paul, Ph.D. (Committee Member)
Jo El Schultz, Ph.D. (Committee Member)
Saulius Sumanas, Ph.D. (Committee Member)
165 p.
Biology
zebrafish; hypercholesterolemia; natural products; complementary and alternative medicine; plant products;

Recommended Citations

Citations

  • Littleton, R. M. (2012). Plant-Based Compound Treatment of Hypercholesterolemia in the Zebrafish [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1355501728

    APA Style (7th edition)

  • Littleton, Robert. Plant-Based Compound Treatment of Hypercholesterolemia in the Zebrafish. 2012. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1355501728.

    MLA Style (8th edition)

  • Littleton, Robert. "Plant-Based Compound Treatment of Hypercholesterolemia in the Zebrafish." Doctoral dissertation, University of Cincinnati, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1355501728

    Chicago Manual of Style (17th edition)

ucin1355501728
489
© 2012, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.
Release 3.2.12