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Risk Factors Associated with Prematurity in Patients Diagnosed with Hypospadias

Tannenbaum, Rebecca L
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024479

Abstract Details

2013, MS, University of Cincinnati, Medicine: Genetic Counseling.
Hypospadias is a birth defect of males in which the urethral meatus, is abnormally located on the ventral side of the penis. Studies have shown an association between prematurity and hypospadias, suggesting that common factors have an impact on both IUGR and hypospadias via a common mechanism of placental insufficiency. Using patients diagnosed with hypospadias, we assessed the association of prematurity with the severity of hypospadias, as well as some other risk factors. Methods: A retrospective chart review of patients diagnosed with hypospadias born either prematurely or full term was completed. Association was tested with logistic models. Results: 210 patients were analyzed. 157 were born full term and 53 were born prematurely. A marginal significant plurality and severity interaction was detected (p=0.069), suggesting that different prematurity-severity association may exist in singletons compared with multiples. In the subsequent stratified analyses, significant association was detected between prematurity and severity in singletons (p=0.020, Fisher'ss exact test). In addition, almost half of all the premature newborn males diagnosed with hypospadias also were diagnosed with a musculoskeletal congenital anomaly. Conclusions: There is a need to investigate if an underlying vascular disruption is associated with prematurity and severity of hypospadias. In addition, there is a need to explore the correlation between musculoskeletal abnormalities and hypospadias in babies born prematurely.
Howard Saal, M.D. (Committee Chair)
Jodie Johnson, M.S., C.G.C. (Committee Member)
Pramod Reddy, M.D. (Committee Member)
Xue Zhang, Ph.D. (Committee Member)
22 p.
Surgery
Hypospadias; Prematurity; Genetic Counseling;

Recommended Citations

Citations

  • Tannenbaum, R. L. (2013). Risk Factors Associated with Prematurity in Patients Diagnosed with Hypospadias [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024479

    APA Style (7th edition)

  • Tannenbaum, Rebecca. Risk Factors Associated with Prematurity in Patients Diagnosed with Hypospadias. 2013. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024479.

    MLA Style (8th edition)

  • Tannenbaum, Rebecca. "Risk Factors Associated with Prematurity in Patients Diagnosed with Hypospadias." Master's thesis, University of Cincinnati, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024479

    Chicago Manual of Style (17th edition)

ucin1368024479
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© 2013, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.