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The role of muscle segment homeobox genes in early pregnancy events

Cha, Jeeyeon
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1377871689

Abstract Details

2013, PhD, University of Cincinnati, Medicine: Molecular and Developmental Biology.
An effective bidirectional communication between an implantation-competent blastocyst and the receptive uterus is a prerequisite for mammalian reproduction. The blastocyst will implant only when this molecular cross-talk is established. Muscle segment homeobox gene (Msh) family members Msx1 and Msx2, which are two highly conserved genes critical for epithelial-mesenchymal interactions with overlapping function during development, also play crucial roles in embryo implantation. Msx1 is transiently expressed in the pregnant uterus during the window of receptivity from day 3 of pregnancy until the morning of day 4 with rapid downregulation with impending implantation. Uterine inactivation of Msx genes leads to infertility due to implantation failure, which correlates with altered uterine luminal epithelial cell polarity and affects E-cadherin/β-catenin complex formation through the transcriptional regulation of Wnt5a expression. Application of Wnt5a in vitro compromised blastocyst invasion and trophoblast outgrowth by cultured uterine epithelial cells.
Sudhansu K. Dey, Ph.D. (Committee Chair)
Stuart Handwerger, M.D. (Committee Member)
Sanjoy K. Das, Ph.D. (Committee Member)
Gurjit Hershey, M.D. Ph.D. (Committee Member)
Alan Jobe, M.D. Ph.D. (Committee Member)
Jeffrey Whitsett, M.D. (Committee Member)
108 p.
Developmental Biology
Msx genes; uterus; embryo implantation; embryonic diapause; delayed implantation; Wnt5a

Recommended Citations

Citations

  • Cha, J. (2013). The role of muscle segment homeobox genes in early pregnancy events [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1377871689

    APA Style (7th edition)

  • Cha, Jeeyeon. The role of muscle segment homeobox genes in early pregnancy events. 2013. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1377871689.

    MLA Style (8th edition)

  • Cha, Jeeyeon. "The role of muscle segment homeobox genes in early pregnancy events." Doctoral dissertation, University of Cincinnati, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1377871689

    Chicago Manual of Style (17th edition)

ucin1377871689
501
© 2013, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.