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Assessment of Manganese Dietary Intake for a Rural Pediatric Population

Zipkin, Frida
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396523208

Abstract Details

2014, PhD, University of Cincinnati, Medicine: Epidemiology (Environmental Health).
Manganese (Mn) is an essential nutrient to humans. While Mn deficiency is extremely rare in humans, toxicity due to overexposure is more prevalent and potentially harmful. Toxicity occurs almost exclusively from excessive environmental exposure in water or air. When studying Mn toxicity, it is important to account for that portion of Mn which is acquired from food sources. Assessing dietary Mn intake in a systematic and accurate way is vital to the scientific identification of pediatric (and adult) populations at risk. Given that the majority of Mn exposure for a typical population comes from diet, it is important to develop a reliable tool to measure dietary Mn intake. To date, no assessment tool has been validated against a Mn biological marker. The main purpose of this study was to develop and validate a Food Frequency Questionnaire (FFQ) to measure dietary Mn intake in a pediatric Appalachian population by comparing the estimated intakes of Mn with corresponding measures of Mn in blood and hair. The FFQ was developed to capture the diverse diet of the Appalachian pediatric population with emphasis on foods rich in Mn. The FFQ was constructed after the Dietary Guidelines for Americans published by the U.S. Government in 2005. A cover page of the FFQ contained detailed instructions on how to complete the questionnaires. The FFQ listed 115 food items, 3 portion sizes, and 6 frequencies of intake. Data were collected between 2009 and 2012 from children ages 7 to 9 years who participated in the Communities Actively Researching Exposure Study (CARES). CARES recruited 404 children. Accurate FFQ data was collected on 375 children. Hair samples were analyzed for Mn and blood samples was analyzed for Mn and serum ferritin concentrations. Nutritional data obtained from the FFQ was restricted to energy and selected nutrients of interest. Pearson’s correlation coefficients matrix were used to investigate the association between dietary and biological data. Results showed that dietary Mn was not correlated with either blood or hair Mn; however, dietary Mn and serum ferritin were significantly and inversely correlated with correlation coefficient of -0.51, P=0.001. Moreover, dietary iron (Fe) and serum ferritin were significantly correlated with a correlation coefficient of 0.51, P=0.001. The proposed FFQ is valid due to the strong association between dietary Fe and Fe measures. Given the small number of subjects in this validation study, further development of the FFQ would likely improve its use in larger studies. Specific recommendations for future research improvement are summarized for upcoming studies utilizing this Mn FFQ.
Erin Nicole Haynes, Dr. P.H. (Committee Chair)
Graciela Falciglia, Ph.D. (Committee Member)
Paul Succop, Ph.D. (Committee Member)
89 p.
Epidemiology
Manganese dietary exposure; Food Frequency Questionnaire; Children; Manganse; Food Frequency Questionnaire validation; Food Frequency Questionnaire development

Recommended Citations

Citations

  • Zipkin, F. (2014). Assessment of Manganese Dietary Intake for a Rural Pediatric Population [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396523208

    APA Style (7th edition)

  • Zipkin, Frida. Assessment of Manganese Dietary Intake for a Rural Pediatric Population. 2014. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396523208.

    MLA Style (8th edition)

  • Zipkin, Frida. "Assessment of Manganese Dietary Intake for a Rural Pediatric Population." Doctoral dissertation, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396523208

    Chicago Manual of Style (17th edition)

ucin1396523208
467
© 2014, some rights reserved.Creative Commons License Assessment of Manganese Dietary Intake for a Rural Pediatric Population by Frida Zipkin is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.