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Developing Green One-Step Organic Reactions in the High Speed Ball Mill

Cook, Teresa L.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397736534

Abstract Details

2014, PhD, University of Cincinnati, Arts and Sciences: Chemistry.
In recent years, a great deal of effort has been put towards developing a more environmentally conscious America. Green chemistry has resulted from tragic environmental events in the past and the desire to prevent such incidents in the future. The United States Environmental Protection Agency describes green chemistry as the “design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Our lab uses a solvent-free method known as high speed ball milling (HSBM) as a way to conduct environmentally friendly organic reactions. HSBM works by placing reagents and a mixing ball inside a reaction vial and shaking it vigorously. The mechanical energy generated during the process of mixing and shaking is enough to overcome the activation barrier of the reaction. This dissertation will describe how the HSBM has successfully been used to conduct “click”, acid-base and aromatic substitution reactions. Each of these reactions has been carried out in a green, one-step method and will be discussed in more detail in their respective chapters. We believe this environmentally friendly, solvent-free technique is a viable alternative to solution-based organic reactions and can transform the way organic chemist approach their profession.
James Mack, Ph.D. (Committee Chair)
Bruce Ault, Ph.D. (Committee Member)
Hairong Guan, Ph.D. (Committee Member)
187 p.
Chemistry
green chemistry; high speed ball milling; green one-step reactions; click reactions; acid-base reactions; aromatic substitution

Recommended Citations

Citations

  • Cook, T. L. (2014). Developing Green One-Step Organic Reactions in the High Speed Ball Mill [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397736534

    APA Style (7th edition)

  • Cook, Teresa. Developing Green One-Step Organic Reactions in the High Speed Ball Mill. 2014. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397736534.

    MLA Style (8th edition)

  • Cook, Teresa. "Developing Green One-Step Organic Reactions in the High Speed Ball Mill." Doctoral dissertation, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397736534

    Chicago Manual of Style (17th edition)

ucin1397736534
722
© 2014, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.
Release 3.2.12