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Wearable and Unobtrusive Electronic Sensor Platform for Biomarker Sensing and Monitoring in Sweat

Rose, Daniel P.
http://orcid.org/0000-0001-5411-9881
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479815632749354

Abstract Details

2016, PhD, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
The rising cost of health care in America is one of the greatest concerns of our time, and perhaps stands to benefit the most from technological innovation and new science. Biomarker testing and detection is not a new concept; blood and urine tests have employed it for decades. However, tests such as these are costly, slow, and invasive, and typically require large, expensive laboratory settings. Still, ever-growing lists of biomarkers found in blood are being observed in similar concentrations in human sweat. Biosensing in sweat requires a fast and efficient way to measure and communicate biomarker concentrations, and thus opens the door to a whole new way of monitoring personal health, evaluating consumer products, mitigating occupational risks and diagnosing illness. While sweat has a distinct advantage in terms of the ease and comfort of accessibility it has, until recently, been largely overlooked as a source of biomarker analytes compared to the more well-established biofluids such as blood, urine and saliva. Some of these traditional biofluids, though less invasively accessed than blood, may well be inferior to sweat in that the biomarker information they contain suffers from interferons or background noise and reduces the target analyte signature. Developing biosensing in sweat requires significant innovation in both scientific and engineering aspects to advance research and technology in this field. Presented in this dissertation is the first-ever wearable RFID patch for measuring of ions/electrolytes in sweat, and a more advanced electronic platform with data-logging capability, Bluetooth Low-Energy wireless communications, and advanced processing and control capabilities for current and future integration of diverse sensing modalities. These platforms demonstrate wearable and unobtrusive electronic devices for biomarker sensing and monitoring in sweat through the use of flexible printed circuit materials, miniaturized and modern surface mounted electronic components, innovative flexible sensor materials and fabrication techniques, and advanced medical-grade textiles and adhesives. Finally, a discussion regarding the present and future applications of sweat sensing devices is presented, which also provides direction for areas of future work.
Jason Heikenfeld, Ph.D. (Committee Chair)
Joshua A. Hagen, Ph.D. (Committee Member)
Fred Beyette, Ph.D. (Committee Member)
William Heineman, Ph.D. (Committee Member)
Ian Papautsky, Ph.D. (Committee Member)
515 p.
Engineering
Sweat Senor; Sweat Monitoring; Sweat sensing; biomarker sensing; RFID patch

Recommended Citations

Citations

  • Rose, D. P. (2016). Wearable and Unobtrusive Electronic Sensor Platform for Biomarker Sensing and Monitoring in Sweat [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479815632749354

    APA Style (7th edition)

  • Rose, Daniel. Wearable and Unobtrusive Electronic Sensor Platform for Biomarker Sensing and Monitoring in Sweat. 2016. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479815632749354.

    MLA Style (8th edition)

  • Rose, Daniel. "Wearable and Unobtrusive Electronic Sensor Platform for Biomarker Sensing and Monitoring in Sweat." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479815632749354

    Chicago Manual of Style (17th edition)

ucin1479815632749354
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© 2016, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.