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Substitution Reactions in the High Speed Ball Mill

Hopgood, Heather M
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816113315302

Abstract Details

2016, PhD, University of Cincinnati, Arts and Sciences: Chemistry.
As environmental concerns are becoming more prominent in today’s society through a modern environmental movement, Green Chemistry has evolved with the effort to reduce the harmful impact of chemical waste. Ideally, Green Chemists would be able to eliminate all hazardous and wasteful components of their experiments. With that lofty goal, a series of principles have been outlined which guide chemists in synthetic design and implementation towards safety and waste reduction. Following this approach, the Mack group has adapted a solventless method which uses high speed ball milling. Since the role of the solvent is to break-down the reagents and disperse the molecules so that a reaction can occur, the ball mill replicates this process through shaking and mixing. Although this process has been applied to a wide range of chemical reactions, the fundamental principles are still not fully understood in the context of a solvent-free system. In order for these new Green Chemistry methodologies to be adopted, these knowledge gaps must be filled. Substitution reactions encompass one of the largest categories of organic chemistry and this work seeks to elucidate the similarities and differences with known solution reactivity.
James Mack, Ph.D. (Committee Chair)
Anna Gudmundsdottir, Ph.D. (Committee Member)
Patrick Limbach, Ph.D. (Committee Member)
David Smithrud, Ph.D. (Committee Member)
138 p.
Chemistry
Green Chemistry; High Speed Ball Milling; Substitution; Enolates; Solvent-free

Recommended Citations

Citations

  • Hopgood, H. M. (2016). Substitution Reactions in the High Speed Ball Mill [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816113315302

    APA Style (7th edition)

  • Hopgood, Heather. Substitution Reactions in the High Speed Ball Mill. 2016. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816113315302.

    MLA Style (8th edition)

  • Hopgood, Heather. "Substitution Reactions in the High Speed Ball Mill." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816113315302

    Chicago Manual of Style (17th edition)

ucin1479816113315302
469
© 2016, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.