Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


32870.pdf (2.08 MB)

ETD Abstract Container

Abstract Header

Understanding Outcomes in the Giant Omphalocele Population: An In-depth Look at a Single Center Comprehensive Experience

Nolan, Heather R
http://orcid.org/0000-0002-5127-1711
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554120110247392

Abstract Details

2019, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Background/Purpose: Overall morbidity and mortality in the giant omphalocele population is complicated not only by the large size of the defect and the associated physiologic aberrancies but also by the propensity for these patients to have other congenital anomalies. Appropriate understanding of these characteristics in addition to surgical options and outcomes is crucial to optimizing patient care. Methods: A retrospective chart review from June 2009 to December of 2018 at a single academic children’s hospital identified 35 patients with giant omphalocele who met criteria for further analysis. Patients were categorized into favorable (n=20) or unfavorable (n=15) outcomes based on mortality and operative morbidity. Odds ratios were then used to analyze potential prenatal and postnatal predictors of overall outcome. Survivors were then further stratified into staged (n=11), delayed (n=8), and primary (n=6) cohorts for subgroup analysis of surgery specific outcomes. Results: Unfavorable outcomes were most notably associated with other major congenital anomalies, sac rupture, major cardiac anomalies, and prematurity and were significantly less likely with increasing birth weight (p=0.0002). In the survivors, the staged repair group had significantly more trips to the operating room prior to fascial closure (p=0.0046), the primary group was younger at the time of repair (p=0.0007) and had shorter length of stay (hospital p=0.0161, NICU p=0.0046); however no other outcomes were found to be significantly different between the three groups including sepsis, ventilator days, or recurrent hernia. Conclusion: Predictions of overall outcomes in the giant omphalocele population requires analysis of multiple patient variables. In those that survive to repair, more research is necessary to determine superiority between repair types.
Patrick Ryan, Ph.D. (Committee Chair)
Todd Jenkins, Ph.D. (Committee Member)
Foong-Yen Lim (Committee Member)
21 p.
Surgery
giant omphaocele; abdominal wall defect; staged omphalocele closure; delayed omphalocele closure

Recommended Citations

Citations

  • Nolan, H. R. (2019). Understanding Outcomes in the Giant Omphalocele Population: An In-depth Look at a Single Center Comprehensive Experience [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554120110247392

    APA Style (7th edition)

  • Nolan, Heather. Understanding Outcomes in the Giant Omphalocele Population: An In-depth Look at a Single Center Comprehensive Experience. 2019. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554120110247392.

    MLA Style (8th edition)

  • Nolan, Heather. "Understanding Outcomes in the Giant Omphalocele Population: An In-depth Look at a Single Center Comprehensive Experience." Master's thesis, University of Cincinnati, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554120110247392

    Chicago Manual of Style (17th edition)

ucin1554120110247392
182
© 2019, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.