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A Study of Cardiometabolic Traits and their Progression, over a Decade, in a Croatian Island Population

Vaitinadin, Nataraja Sarma
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554475800173427

Abstract Details

2019, PhD, University of Cincinnati, Medicine: Epidemiology (Environmental Health).
Abstract The growth of computation and big data have allowed us to ask more and more complex questions about healthcare. One of the key questions being asked is about using data to predict outcomes. With the alarming rise in cardiometabolic diseases, and associated healthcare costs, it is about time to focus energy and resources on developing methodologies to predict disease status in the future. We have implemented a productive workflow that takes data from epidemiologic field studies, to develop prediction models to determine disease status a decade into the future. The models were tested for accuracy and were used to develop a diagnostic test. The test was validated using an ROC (Receiver Operating Characteristic) curve. Further, the model was cross validated on untrained data. The robustness of the approach was demonstrated across four different disease outcomes – high blood pressure, coronary heart disease, diabetes and gout. We further examined changes in biomarker measurements at the population level, over time and with sex. Both these approaches target two important aspects of public health – precision medicine and population health. To that extent, the study is a successful demonstration of utilizing field data to develop and test contrasting research questions – at the individual level and at the population level, simultaneously.
Ranjan Deka, Ph.D. (Committee Chair)
Aimin Chen, Ph.D. (Committee Member)
Roman Jandarov, Ph.D. (Committee Member)
Jane Khoury, Ph.D. (Committee Member)
103 p.
Epidemiology
cardiometabolic; predictive; epidemiology; complex traits; ROC; Croatia

Recommended Citations

Citations

  • Vaitinadin, N. S. (2019). A Study of Cardiometabolic Traits and their Progression, over a Decade, in a Croatian Island Population [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554475800173427

    APA Style (7th edition)

  • Vaitinadin, Nataraja Sarma. A Study of Cardiometabolic Traits and their Progression, over a Decade, in a Croatian Island Population. 2019. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554475800173427.

    MLA Style (8th edition)

  • Vaitinadin, Nataraja Sarma. "A Study of Cardiometabolic Traits and their Progression, over a Decade, in a Croatian Island Population." Doctoral dissertation, University of Cincinnati, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554475800173427

    Chicago Manual of Style (17th edition)

ucin1554475800173427
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© 2019, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.
Release 3.2.12