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Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis

Gulati, Ruhi
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353

Abstract Details

2019, MS, University of Cincinnati, Medicine: Biomedical Research Technology.
Epilepsy is a crippling neurological condition that is characterized by episodes of unprovoked seizures. Current antiepileptic drugs are effective at controlling seizures, but do not cure or modify the disease, and are ineffective for a third of the patient population with epilepsy. There are no clinically proven preventatives for patients at risk of developing epilepsy. The mTOR pathway has emerged as a promising new target as a disease-modifying therapy for epilepsy. Circumstantial evidence has linked mTOR to epileptogenesis through hyper activated signaling identified in acute seizures, status epilepticus, and traumatic brain injuries, yet the underlying mechanisms behind these effects remain unclear. mTOR signaling has been found to be dramatically increased in the dentate gyrus during temporal lobe epileptogenesis. The studies reported in this thesis look at the mTOR project from different projects: 1) Developing viral strategies to selectively delete mTOR from the Hippocampus and 2) Developing a model of Focal Cortical Dysplasia.
Rolf Stottmann, PhD (Committee Chair)
Steve Danzer, Ph.D. (Committee Member)
Christina Gross, Ph.D. (Committee Member)
14 p.
Neurology
Epilepsy; mTOR hyperactivation; mTOR; stereotaxic surgery; PTEN

Recommended Citations

Citations

  • Gulati, R. (2019). Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353

    APA Style (7th edition)

  • Gulati, Ruhi. Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis. 2019. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353.

    MLA Style (8th edition)

  • Gulati, Ruhi. "Developing Viral Strategies to Study mTOR and its Regulators as Mediators of Epileptogenesis." Master's thesis, University of Cincinnati, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1563273811946353

    Chicago Manual of Style (17th edition)

ucin1563273811946353
287
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This open access ETD is published by University of Cincinnati and OhioLINK.