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Applications of Hyperpolarized 129-Xenon Magnetic Resonance Imaging in Pediatric Asthma

Lin, Nancy Y
http://orcid.org/0000-0003-0800-2783
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268100652155

Abstract Details

2020, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Background: There have been significant advances in treatment for severe asthma in the past decade, but there are no diagnostic tests sensitive to changes in regional lung ventilation in pediatric asthma. Measurements of regional lung ventilation with hyperpolarized 129Xe magnetic resonance imaging (129Xe MRI) in childhood asthma do not require ionizing radiation and are poised to advance our understanding of disease mechanisms in a highly spatially heterogeneous disease, leading to improved outcomes. Objective: The purpose of this study was to examine the relationship between 129Xe MRI, functional measures, and clinical severity in a cohort of pediatric asthma subjects. Methods: Thirty-seven children (13 severe asthma, 7 mild/moderate asthma, 17 age-matched healthy controls) aged 5-18 years old were imaged with 129Xe MRI. Ventilation defect percentage (VDP) and image reader score were calculated and compared to spirometry and clinical severity at baseline (12 months before MRI) and at follow-up (up to 12 months after MRI).
Scott Langevin, Ph.D. (Committee Chair)
Theresa Guilbert, M.D., M.S. (Committee Member)
Md Monir Hossain, Ph.D. (Committee Member)
Jason Woods, Ph.D. (Committee Member)
30 p.
Surgery
Asthma; Pediatric; Hyperpolarized MRI; spirometry; healthcare utilization; clinical severity

Recommended Citations

Citations

  • Lin, N. Y. (2020). Applications of Hyperpolarized 129-Xenon Magnetic Resonance Imaging in Pediatric Asthma [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268100652155

    APA Style (7th edition)

  • Lin, Nancy. Applications of Hyperpolarized 129-Xenon Magnetic Resonance Imaging in Pediatric Asthma. 2020. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268100652155.

    MLA Style (8th edition)

  • Lin, Nancy. "Applications of Hyperpolarized 129-Xenon Magnetic Resonance Imaging in Pediatric Asthma." Master's thesis, University of Cincinnati, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1593268100652155

    Chicago Manual of Style (17th edition)

ucin1593268100652155
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This open access ETD is published by University of Cincinnati and OhioLINK.