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36753.pdf (6.02 MB)
ETD Abstract Container
Abstract Header
Transcranial Ultrasound for the Treatment of Stroke
Author Info
Kleven, Robert T
ORCID® Identifier
http://orcid.org/0000-0001-6606-3010
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595848922517413
Abstract Details
Year and Degree
2020, PhD, University of Cincinnati, Engineering and Applied Science: Biomedical Engineering.
Abstract
Recent advances in point of care clinical diagnostic ultrasound scanners and image-guided procedures have been accompanied by an exponential expansion of therapeutic ultrasound technologies. Treatment strategies for stroke, a leading cause of morbidity and mortality worldwide, have been limited using lytic agents and interventional approaches with poor clinical outcomes. Sonothrombolysis, the adjuvant use of ultrasound exposure to enhance and accelerate thrombus break down with a thrombolytic agent, has been successful in vitro but has lacked demonstration of clinical success in large randomized controlled stroke treatment trials to date. This dissertation describes the development of unfocused low frequency (= 220 kHz) therapeutic ultrasound to enhance lysis through mechanically agitation and improved lytic diffusion.
Committee
Christy Holland, Ph.D. (Committee Chair)
Kevin Haworth, Ph.D. (Committee Member)
T. Douglas Mast, Ph.D. (Committee Member)
Marepalli Rao, Ph.D. (Committee Member)
Mario Zuccarello, MD (Committee Member)
Pages
145 p.
Subject Headings
Biomedical Research
Keywords
Sonothrombolysis
;
Porcine
;
Stroke
;
Cavitation
;
Recanalization
;
Animal
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Citations
Kleven, R. T. (2020).
Transcranial Ultrasound for the Treatment of Stroke
[Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595848922517413
APA Style (7th edition)
Kleven, Robert.
Transcranial Ultrasound for the Treatment of Stroke.
2020. University of Cincinnati, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595848922517413.
MLA Style (8th edition)
Kleven, Robert. "Transcranial Ultrasound for the Treatment of Stroke." Doctoral dissertation, University of Cincinnati, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595848922517413
Chicago Manual of Style (17th edition)
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Document number:
ucin1595848922517413
Download Count:
83
Copyright Info
© 2020, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.