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Sensitivity to Oral Food Allergies in Subjects with Allergic Rhinitis and Eczema

Syck , Megan Paige
http://orcid.org/0000-0003-1550-4722
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623167438325618

Abstract Details

2021, MS, University of Cincinnati, Medicine: Industrial Hygiene (Environmental Health).
Oral food allergies for the worldwide general population have been on the rise within the past three decades and are becoming a prevalent issue among pediatric patients (Foong et al., 2017; Zhu et al., 2015). Allergic rhinitis and atopic dermatitis (eczema), along with oral food allergies and sensitivities, are all classified as allergic diseases (Foong et al., 2017). Since these diseases are classified as allergic- type diseases, they likely have a higher chance of comorbidity (Foong et al., 2017). If the diseases are truly comorbid, as suggested by Foong et al. (2017), then it may be possible to use documented clinical histories of allergic hypersensitivities as predictors of increased sensitivity to food allergens. This study's objective was to determine if a history of allergic rhinitis or eczema are associated with an increase in severity or sensitivity to specific oral food allergies. Our hypothesis was that study subjects with a history of eczema or allergic rhinitis would have increased sensitivity to oral food allergens compared to participants without a history of eczema or allergic rhinitis. This hypothesis was tested using a data set of 435 total participants enrolled in an oral food allergen desensitization study with positive allergy screening tests for one or more tested foods. Reaction probability to the allergens was calculated based on the allergic responses during the oral challenge phase as the cumulative dose was incrementally increased. The severity of the reaction was determined using a 3-category (1=mild, 3=severe) scale based upon the participants' clinical responses during the challenge. Non-parametric Kaplan Meier event estimates were used to evaluate the dose-response relationship using a censored univariate model, and parametric survival analysis was used to for regression modeling. The severity of reactions was evaluated for participants with and without allergic rhinitis and eczema. A slightly statistically significant relationship was found in participants with cashew allergies and a history of eczema. All other allergens had a p-value greater than 0.05 and were not statistically significant regardless of either disease's history. The results of the statistical analyses did not fully support the iii hypothesis. Future direction and research should be done to determine if additional factors would impact oral food allergies' sensitivity.
John Reichard, PharmD Ph.D. (Committee Chair)
Cynthia Betcher, D.N.P. M.S.N. (Committee Member)
32 p.
Environmental Health

Recommended Citations

Citations

  • Syck , M. P. (2021). Sensitivity to Oral Food Allergies in Subjects with Allergic Rhinitis and Eczema [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623167438325618

    APA Style (7th edition)

  • Syck , Megan . Sensitivity to Oral Food Allergies in Subjects with Allergic Rhinitis and Eczema. 2021. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623167438325618.

    MLA Style (8th edition)

  • Syck , Megan . "Sensitivity to Oral Food Allergies in Subjects with Allergic Rhinitis and Eczema." Master's thesis, University of Cincinnati, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623167438325618

    Chicago Manual of Style (17th edition)

ucin1623167438325618
72
© 2021, some rights reserved.Creative Commons License Sensitivity to Oral Food Allergies in Subjects with Allergic Rhinitis and Eczema by Megan Paige Syck is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.