Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


38293.pdf (4.05 MB)

ETD Abstract Container

Abstract Header

Newly Identified Role for the Transcription Factor Foxp1 in Natural Killer Cells

Kotey, Amos
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1627658577374061

Abstract Details

2021, MS, University of Cincinnati, Medicine: Immunology.
Natural killer (NK) cells are a type of innate lymphoid cell specialized in providing defense against viruses and cells that have undergone transformation. The effector functions of NK cells are primarily mediated through the release of granzyme- and perforin-containing cytoplasmic granules that trigger target cell death. Cytolytic capacity of NK cells increases with functional maturation that is controlled by an imcompletely defined network of transcription factors and cytokines. Here we show that mice with conditional deletion of the transcription factor Foxp1 in the NK cell lineage have decreased proportions and total numbers of NK cells in the spleen and bone marrow. The NK cells that develop in the absence of Foxp1 exhibit significant impairment in their maturation profile and cytolytic functions when compared to Foxp1 sufficient NK cells. Yet, induction of interferon gamma (IFN-g) production in response to IL-12 and IL-18 was similar in Foxp1-sufficient and –deficient NK cells. These data provide the first evidence of a role for Foxp1 in NK cell biology and highlight a novel target for strategies aimed at enhancing or engineering NK cells in patients with tumors or infections.
Stephen Waggoner, Ph.D. (Committee Chair)
George Deepe, M.D. (Committee Member)
Jonathan Katz, Ph.D. (Committee Member)
40 p.
Immunology

Recommended Citations

Citations

  • Kotey, A. (2021). Newly Identified Role for the Transcription Factor Foxp1 in Natural Killer Cells [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1627658577374061

    APA Style (7th edition)

  • Kotey, Amos. Newly Identified Role for the Transcription Factor Foxp1 in Natural Killer Cells. 2021. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1627658577374061.

    MLA Style (8th edition)

  • Kotey, Amos. "Newly Identified Role for the Transcription Factor Foxp1 in Natural Killer Cells." Master's thesis, University of Cincinnati, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1627658577374061

    Chicago Manual of Style (17th edition)

ucin1627658577374061
18
© 2021, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.