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Stress Reducing Effects of Oxytocin in a Maternal Separation Paradigm

O’Connell, Keely Jane
http://rave.ohiolink.edu/etdc/view?acc_num=wright1216649062

Abstract Details

2008, Master of Science (MS), Wright State University, Anatomy.
This study compared the effects of centrally and peripherally administered oxytocin (OT) on HPA axis activity and the presence of both stress-induced active and passive behaviors in female guinea pig pups (Cavia porcellus) after 180-min of isolation . In Experiment 1, one dose of oxytocin (10μg/.2ml) was injected subcutaneously into the periphery. Plasma cortisol levels were reduced after 180-min of isolation and two passive behaviors, eye-closure and crouch, were reduced as well with the administration of oxytocin. In Experiment 2, two different doses (10μg/.2ml and 20μg/.2ml) were injected into the periphery with no significant results. In Experiment 3 one dose of oxytocin (1μg/5μl) was infused centrally. Plasma cortisol levels were marginally reduced after 30-min of isolation. Both the active and passive behaviors were unchanged.
Michael Hennessy, PhD (Advisor)
Dragana Claflin, PhD (Committee Member)
John Pearson, PhD (Committee Member)
Patricia Schiml-Webb, PhD (Committee Member)
54 p.
Behaviorial Sciences
oxytocin; stress; maternal separation; guinea pigs

Recommended Citations

Citations

  • O’Connell, K. J. (2008). Stress Reducing Effects of Oxytocin in a Maternal Separation Paradigm [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1216649062

    APA Style (7th edition)

  • O’Connell, Keely. Stress Reducing Effects of Oxytocin in a Maternal Separation Paradigm. 2008. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1216649062.

    MLA Style (8th edition)

  • O’Connell, Keely. "Stress Reducing Effects of Oxytocin in a Maternal Separation Paradigm." Master's thesis, Wright State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1216649062

    Chicago Manual of Style (17th edition)

wright1216649062
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© 2008, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.