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Inhibition of pro-inflammatory processes reduces sensitization of the behavioral response to maternal separation

Paik, Kristopher Doojin
http://rave.ohiolink.edu/etdc/view?acc_num=wright1253372041

Abstract Details

2009, Master of Science (MS), Wright State University, Anatomy.
The current study examined the behavioral sensitization of guinea pig pups in response to consecutive days of maternal separation. In the first experiment, guinea pigs that received centrally administered artificial cerebrospinal fluid or IL-10 exhibited sensitization of passive behaviors from Day 1 to Day 2. IL-10 decreased the levels of passive behaviors on Day 1, as well as the increase on Day 2. The second experiment used unoperated pups, which also showed sensitization of the passive response from Day 1 to Day 2, though the effect appeared reduced relative to control pups of Experiment 1. Collectively, this investigation confirms previous evidence that passive behaviors are due in part to pro-inflammatory cytokines. It also provides evidence that the increase in passive measures from the first separation to the second may be caused by a sensitization of pro-inflammatory mechanisms.
Michael Hennessy (Advisor)
Patricia Schiml-Webb (Committee Member)
John Pearson (Committee Member)
48 p.
Psychology
pro-inflammatory cytokines; maternal separation; sensitization; depression; guinea pigs

Recommended Citations

Citations

  • Paik, K. D. (2009). Inhibition of pro-inflammatory processes reduces sensitization of the behavioral response to maternal separation [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1253372041

    APA Style (7th edition)

  • Paik, Kristopher. Inhibition of pro-inflammatory processes reduces sensitization of the behavioral response to maternal separation. 2009. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1253372041.

    MLA Style (8th edition)

  • Paik, Kristopher. "Inhibition of pro-inflammatory processes reduces sensitization of the behavioral response to maternal separation." Master's thesis, Wright State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1253372041

    Chicago Manual of Style (17th edition)

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© 2009, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.