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SURFACE MODIFICATION OF CARBON STRUCTURES FOR BIOLOGICAL APPLICATIONS

Maurer, Elizabeth Irene
http://rave.ohiolink.edu/etdc/view?acc_num=wright1292621438

Abstract Details

2010, Master of Science in Engineering (MSEgr), Wright State University, Materials Science and Engineering.
Carbon substrates have a wide variety of applications, many of which are enabled by appropriate surface modifications. In particular, the use of carbon-based substrates for biological devices can be quite advantageous due to their relative inertness and biocompatibility. Moreover, graphitic carbon can take many forms ranging from flat sheets to foams, fibers, and nanotubes. In this project, larger carbon substrates such as microcellular foam and flat graphite have been modified with carbon nanotubes, and their potential use in two types of biological applications was tested. The first study involved an investigation of the growth and proliferation of osteoblast cells on carbon, so that such structures can be evaluated for possible use as a scaffold for in-vivo tissue regeneration. The surface modifications that were compared are a collagen coating, a silica film, and a strongly adhered carbon nanotube layer. It was seen that the attachment of carbon nanotubes led to the highest density and viability of osteoblast cells on the surface indicating their potential benefit in implant and cell scaffolding applications. In the second study, carbon nanotubes were attached on the graphite, and subsequently decorated with gold nanoparticles and a ribonucleic acid (RNA) sequence. These nano-structures show advantages in detecting the DH5α E. coli bacterial strain, indicating potential use as a biosensor. Proof-of-concept results indicate increased attachment of gold nanoparticles coated with an RNA capture element compared to uncoated particles onto the E. coli. This demonstrates the potential use of this concept in creation of a multi-array sensor for fast and sensitive detection of many types of pathogens. These results clearly show that attachment of carbon nanotubes on larger carbon substrates can provide the basis for several unique biological devices.
Sharmila Mukhopadhyay, PhD (Advisor)
Saber Hussain, PhD (Committee Member)
Allen Jackson, PhD (Committee Member)
56 p.
Biomedical Engineering; Engineering; Materials Science; Nanotechnology
carbon structure; surface modification; carbon nanotube; gold nanoparticle; biosensor; scaffold;

Recommended Citations

Citations

  • Maurer, E. I. (2010). SURFACE MODIFICATION OF CARBON STRUCTURES FOR BIOLOGICAL APPLICATIONS [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1292621438

    APA Style (7th edition)

  • Maurer, Elizabeth. SURFACE MODIFICATION OF CARBON STRUCTURES FOR BIOLOGICAL APPLICATIONS. 2010. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1292621438.

    MLA Style (8th edition)

  • Maurer, Elizabeth. "SURFACE MODIFICATION OF CARBON STRUCTURES FOR BIOLOGICAL APPLICATIONS." Master's thesis, Wright State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1292621438

    Chicago Manual of Style (17th edition)

wright1292621438
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© 2010, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.