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Effects of elevated glucocorticoid levels on dentate gyrus development

Vallandingham, Zachary Dale
http://rave.ohiolink.edu/etdc/view?acc_num=wright1341348410

Abstract Details

2012, Master of Science (MS), Wright State University, Anatomy.
Exogenous glucocorticoids are commonly used in modern medications and animal studies examining the effects of glucocorticoids on the developing brain report inconsistent results. Recent reports have questioned the reliability of available drug delivery methods in mice (Herrmann et al., 2009). In our laboratory, variable behavioral results using trace eyeblink conditioning (EBC) suggest that we may be having similar problems delivering glucoroticoids to developing rat pups (Claflin et al., 2005, 2011). Subcutaneous pellets and osmotic minipumps resulted in impaired learning during trace eyeblink conditioning whereas subcutaneous injection of corticosterone (CORT) resulted in facilitation of learning on the same task. One of the possible mechanisms for CORT-induced cognitive effects may be changes to hippocampal development, specifically neurogenesis. We examined potential differences in hippocampal neurogenesis for rats subjected to elevated CORT levels as in the aforementioned behavioral studies. For the present report, exogenous administration of CORT was achieved using subcutaneous pellets. CORT- treated males showed significantly less neurogenesis than the CORT treated females. Furthermore, males of the control group showed significantly more neurogenesis than the females.
Dragana Claflin, PhD (Advisor)
Dragana Claflin, PhD (Committee Member)
Michael Hennessy, PhD (Committee Member)
Larry Ream, PhD (Committee Member)
Andrew Hsu, PhD (Other)
Timothy Cope, PhD (Other)
52 p.
Neurobiology
neurobiology

Recommended Citations

Citations

  • Vallandingham, Z. D. (2012). Effects of elevated glucocorticoid levels on dentate gyrus development [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1341348410

    APA Style (7th edition)

  • Vallandingham, Zachary. Effects of elevated glucocorticoid levels on dentate gyrus development. 2012. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1341348410.

    MLA Style (8th edition)

  • Vallandingham, Zachary. "Effects of elevated glucocorticoid levels on dentate gyrus development." Master's thesis, Wright State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1341348410

    Chicago Manual of Style (17th edition)

wright1341348410
502
© 2012, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.